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    Styxl2 serine/threonine/tyrosine interacting like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498267, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Styxl2provided by RGD
    Official Full Name
    serine/threonine/tyrosine interacting like 2provided by RGD
    Primary source
    RGD:1560598
    See related
    EnsemblRapid:ENSRNOG00000003722 AllianceGenome:RGD:1560598
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dusp27; RGD1560598
    Summary
    Predicted to enable MAP kinase phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. Predicted to be involved in negative regulation of MAPK cascade. Predicted to be active in cytoplasm. Orthologous to human STYXL2 (serine/threonine/tyrosine interacting like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 212.9) and Heart (RPKM 128.2) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Styxl2 in Genome Data Viewer
    Location:
    13q23
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (80882341..80911458, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (78349361..78378480, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (84302824..84332899, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene POU class 2 homeobox 1 Neighboring gene uncharacterized LOC134481526 Neighboring gene glycoprotein A33 Neighboring gene cold shock domain-containing protein E1-like Neighboring gene maelstrom spermatogenic transposon silencer

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1. Yuan L, et al. Cardiovasc Res, 2023 Mar 17. PMID 35352799
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables MAP kinase phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine/tyrosine-interacting-like protein 2
    Names
    dual specificity phosphatase 27 (putative)
    dual specificity phosphatase 27, atypical
    inactive dual specificity phosphatase 27

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191929.2 → NP_001178858.1  serine/threonine/tyrosine-interacting-like protein 2

      See identical proteins and their annotated locations for NP_001178858.1

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      D3ZRM0
      Conserved Domains (1) summary
      cd00127
      Location:133 → 275
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

    2. NM_001429955.1 → NP_001416884.1  serine/threonine/tyrosine-interacting-like protein 2

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      D3ZRM0

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      80882341..80911458 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250187.5 → XP_006250249.1  serine/threonine/tyrosine-interacting-like protein 2 isoform X1

      Related
      ENSRNOP00000004965.3, ENSRNOT00000004965.7
      Conserved Domains (1) summary
      cd00127
      Location:133 → 275
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

    2. XM_006250188.5 → XP_006250250.1  serine/threonine/tyrosine-interacting-like protein 2 isoform X1

      Conserved Domains (1) summary
      cd00127
      Location:133 → 275
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    Nucleotide Protein Strain
    Heading Accession and Version

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