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    Zpbp2 zona pellucida binding protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363676, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zpbp2provided by RGD
    Official Full Name
    zona pellucida binding protein 2provided by RGD
    Primary source
    RGD:1549726
    See related
    EnsemblRapid:ENSRNOG00000007255 AllianceGenome:RGD:1549726
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in acrosome assembly and binding activity of sperm to zona pellucida. Predicted to act upstream of or within membrane lipid metabolic process and regulation of gene expression. Predicted to be located in cell body. Predicted to be part of zona pellucida receptor complex. Predicted to be active in acrosomal vesicle. Orthologous to human ZPBP2 (zona pellucida binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 72.3), Thymus (RPKM 19.1) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zpbp2 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (84055184..84063776)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (83558772..83567511)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (86513645..86523375)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene IKAROS family zinc finger 3 Neighboring gene uncharacterized LOC134480865 Neighboring gene U6 spliceosomal RNA Neighboring gene ORMDL sphingolipid biosynthesis regulator 3 Neighboring gene leucine rich repeat containing 3C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Loss of the zona pellucida-binding protein 2 (Zpbp2) gene in mice impacts airway hypersensitivity and lung lipid metabolism in a sex-dependent fashion. Kanagaratham C, et al. Mamm Genome, 2018 Apr. PMID 29536159
    2. Loss of zona pellucida binding proteins in the acrosomal matrix disrupts acrosome biogenesis and sperm morphogenesis. Lin YN, et al. Mol Cell Biol, 2007 Oct. PMID 17664285, Free PMC Article
    3. The chaperonin containing TCP1 complex (CCT/TRiC) is involved in mediating sperm-oocyte interaction. Dun MD, et al. J Biol Chem, 2011 Oct 21. PMID 21880732, Free PMC Article
    4. Proteomic characterization of the human sperm nucleus. de Mateo S, et al. Proteomics, 2011 Jul. PMID 21630459
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in acrosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within acrosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in binding of sperm to zona pellucida IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in binding of sperm to zona pellucida IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within binding of sperm to zona pellucida ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within circadian regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within membrane lipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of immunoglobulin production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within sphingolipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in acrosomal vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of zona pellucida receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of zona pellucida receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zona pellucida-binding protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007011.1 → NP_001007012.1  zona pellucida-binding protein 2 precursor

      See identical proteins and their annotated locations for NP_001007012.1

      Status: PROVISIONAL

      Source sequence(s)
      BC082007
      UniProtKB/Swiss-Prot
      Q6X781, Q6X782
      Related
      ENSRNOP00000009535.5, ENSRNOT00000009535.8
      Conserved Domains (1) summary
      pfam07354
      Location:55 → 326
      Sp38; Zona-pellucida-binding protein (Sp38)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      84055184..84063776
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269546.1 → XP_063125616.1  zona pellucida-binding protein 2 isoform X11

    2. XM_063269544.1 → XP_063125614.1  zona pellucida-binding protein 2 isoform X7

    3. XM_063269545.1 → XP_063125615.1  zona pellucida-binding protein 2 isoform X8

    4. XM_039086510.2 → XP_038942438.1  zona pellucida-binding protein 2 isoform X12

      Conserved Domains (1) summary
      pfam07354
      Location:78 → 115
      Sp38; Zona-pellucida-binding protein (Sp38)

    5. XM_063269541.1 → XP_063125611.1  zona pellucida-binding protein 2 isoform X4

    6. XM_063269540.1 → XP_063125610.1  zona pellucida-binding protein 2 isoform X2

    7. XM_039086508.2 → XP_038942436.1  zona pellucida-binding protein 2 isoform X9

      Conserved Domains (1) summary
      pfam07354
      Location:94 → 169
      Sp38; Zona-pellucida-binding protein (Sp38)

    8. XM_039086511.2 → XP_038942439.1  zona pellucida-binding protein 2 isoform X13

      Conserved Domains (1) summary
      pfam07354
      Location:39 → 157
      Sp38; Zona-pellucida-binding protein (Sp38)

    9. XM_063269539.1 → XP_063125609.1  zona pellucida-binding protein 2 isoform X1

    10. XM_039086507.2 → XP_038942435.1  zona pellucida-binding protein 2 isoform X3

      Conserved Domains (1) summary
      pfam07354
      Location:149 → 242
      Sp38; Zona-pellucida-binding protein (Sp38)

    11. XM_006247387.5 → XP_006247449.1  zona pellucida-binding protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZK31
      Related
      ENSRNOP00000076458.1, ENSRNOT00000105871.2
      Conserved Domains (1) summary
      pfam07354
      Location:55 → 253
      Sp38; Zona-pellucida-binding protein (Sp38)

    12. XM_039086509.2 → XP_038942437.1  zona pellucida-binding protein 2 isoform X10

      Conserved Domains (1) summary
      pfam07354
      Location:78 → 199
      Sp38; Zona-pellucida-binding protein (Sp38)

    13. XM_063269542.1 → XP_063125612.1  zona pellucida-binding protein 2 isoform X5

      UniProtKB/TrEMBL
      A6HIT1
      Related
      ENSRNOP00000048783.3, ENSRNOT00000048647.6

    14. XM_006247385.5 → XP_006247447.1  zona pellucida-binding protein 2 isoform X5

      See identical proteins and their annotated locations for XP_006247447.1

      UniProtKB/TrEMBL
      A6HIT1
      Conserved Domains (1) summary
      pfam07354
      Location:1 → 272
      Sp38; Zona-pellucida-binding protein (Sp38)

    15. XM_063269543.1 → XP_063125613.1  zona pellucida-binding protein 2 isoform X5

      UniProtKB/TrEMBL
      A6HIT1

    16. XM_006247384.5 → XP_006247446.1  zona pellucida-binding protein 2 isoform X5

      See identical proteins and their annotated locations for XP_006247446.1

      UniProtKB/TrEMBL
      A6HIT1
      Conserved Domains (1) summary
      pfam07354
      Location:1 → 272
      Sp38; Zona-pellucida-binding protein (Sp38)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6X782.1 GenPept UniProtKB/Swiss-Prot:Q6X782

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