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    Abr ABR activator of RhoGEF and GTPase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287537, updated on 9-Dec-2024

    Summary

    Symbol
    Abrprovided by RGD
    Full Name
    ABR activator of RhoGEF and GTPaseprovided by RGD
    Primary source
    RGD:1306279
    See related
    EnsemblRapid:ENSRNOG00000056837 AllianceGenome:RGD:1306279
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTPase activator activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including activation of GTPase activity; negative regulation of blood vessel remodeling; and negative regulation of cellular extravasation. Predicted to act upstream of or within several processes, including negative regulation of macrophage migration; regulation of vesicle-mediated transport; and response to lipopolysaccharide. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Orthologous to human ABR (ABR activator of RhoGEF and GTPase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 421.4), Spleen (RPKM 156.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Abr in Genome Data Viewer
    Location:
    10q24
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (61760743..61959526, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (61262516..61461331, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (64565121..64657079, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene nucleoredoxin Neighboring gene uncharacterized LOC120095143 Neighboring gene translocase of inner mitochondrial membrane 22 Neighboring gene transfer RNA alanine (anticodon UGC) 11 Neighboring gene uncharacterized LOC120095144 Neighboring gene basic helix-loop-helix family, member a9

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity  
    enables GTPase activator activity  
    enables guanyl-nucleotide exchange factor activity  
    enables guanyl-nucleotide exchange factor activity  
    enables protein binding PubMed 
    enables protein serine/threonine kinase activity  
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization  
    involved_in activation of GTPase activity  
    acts_upstream_of_or_within brain development  
    acts_upstream_of cell migration  
    acts_upstream_of establishment of localization in cell  
    acts_upstream_of_or_within inner ear morphogenesis  
    involved_in intracellular signal transduction  
    acts_upstream_of macrophage migration  
    involved_in modulation of chemical synaptic transmission  
    involved_in modulation of chemical synaptic transmission  
    involved_in negative regulation of blood vessel remodeling  
    involved_in negative regulation of cellular extravasation  
    acts_upstream_of_or_within negative regulation of inflammatory response  
    acts_upstream_of_or_within negative regulation of macrophage migration  
    acts_upstream_of_or_within negative regulation of neutrophil degranulation  
    acts_upstream_of_or_within neuromuscular process controlling balance  
    acts_upstream_of neutrophil degranulation  
    acts_upstream_of phagocytosis  
    acts_upstream_of_or_within positive regulation of phagocytosis  
    involved_in regulation of vascular permeability  
    acts_upstream_of_or_within response to lipopolysaccharide  
    involved_in signal transduction  
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse  
    located_in Schaffer collateral - CA1 synapse  
    located_in axon  
    located_in cytosol  
    located_in dendritic spine  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse  
    located_in glutamatergic synapse  
    is_active_in membrane  
    located_in plasma membrane  
    is_active_in postsynaptic density, intracellular component PubMed 

    General protein information

    Preferred Names
    active breakpoint cluster region-related protein
    Names
    ABR, RhoGEF and GTPase activating protein
    active BCR-related
    breakpoint cluster region protein-like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105814.4NP_001099284.1  active breakpoint cluster region-related protein

      See identical proteins and their annotated locations for NP_001099284.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      A0A0G2JTR4
      UniProtKB/TrEMBL
      A0A4X0W8E9, A6HGV7
      Related
      ENSRNOP00000085893.2, ENSRNOT00000098977.2
      Conserved Domains (4) summary
      cd08686
      Location:506626
      C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
      cd00160
      Location:92282
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd04387
      Location:645840
      RhoGAP_Bcr; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr ...
      cd13366
      Location:277460
      PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      61760743..61959526 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085523.2XP_038941451.1  active breakpoint cluster region-related protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6A3Q6
      Related
      ENSRNOP00000085287.1, ENSRNOT00000109843.2
      Conserved Domains (5) summary
      cd08686
      Location:832952
      C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
      cd00160
      Location:418608
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd04387
      Location:9711166
      RhoGAP_Bcr; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr ...
      cd13366
      Location:603786
      PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain
      pfam09036
      Location:367
      Bcr-Abl_Oligo; Bcr-Abl oncoprotein oligomerization domain
    2. XM_039085524.2XP_038941452.1  active breakpoint cluster region-related protein isoform X2

      UniProtKB/TrEMBL
      A0A4X0W8E9
      Related
      ENSRNOP00000068811.3, ENSRNOT00000080703.3
      Conserved Domains (4) summary
      cd08686
      Location:563683
      C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
      cd00160
      Location:149339
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd04387
      Location:702897
      RhoGAP_Bcr; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr ...
      cd13366
      Location:334517
      PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain
    3. XM_039085528.2XP_038941456.1  active breakpoint cluster region-related protein isoform X3

      UniProtKB/TrEMBL
      A0A4X0W8E9, A0A8I6A171
      Related
      ENSRNOP00000105867.1, ENSRNOT00000139836.1
      Conserved Domains (4) summary
      cd08686
      Location:497617
      C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
      cd00160
      Location:83273
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd04387
      Location:636831
      RhoGAP_Bcr; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr ...
      cd13366
      Location:268451
      PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain
    4. XM_039085531.2XP_038941459.1  active breakpoint cluster region-related protein isoform X5

      UniProtKB/TrEMBL
      A0A4X0W8E9
      Related
      ENSRNOP00000107867.1, ENSRNOT00000138045.1
      Conserved Domains (4) summary
      cd08686
      Location:460580
      C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
      cd00160
      Location:46236
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd04387
      Location:599794
      RhoGAP_Bcr; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr ...
      cd13366
      Location:231414
      PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain
    5. XM_039085527.2XP_038941455.1  active breakpoint cluster region-related protein isoform X3

      UniProtKB/TrEMBL
      A0A4X0W8E9, A0A8I6A171
      Conserved Domains (4) summary
      cd08686
      Location:497617
      C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
      cd00160
      Location:83273
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd04387
      Location:636831
      RhoGAP_Bcr; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr ...
      cd13366
      Location:268451
      PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain
    6. XM_039085530.2XP_038941458.1  active breakpoint cluster region-related protein isoform X5

      UniProtKB/TrEMBL
      A0A4X0W8E9
      Conserved Domains (4) summary
      cd08686
      Location:460580
      C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
      cd00160
      Location:46236
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd04387
      Location:599794
      RhoGAP_Bcr; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr ...
      cd13366
      Location:231414
      PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain
    7. XM_039085529.2XP_038941457.1  active breakpoint cluster region-related protein isoform X4

      UniProtKB/TrEMBL
      A0A0G2JZZ7, A0A4X0W8E9
      Related
      ENSRNOP00000071246.1, ENSRNOT00000084670.3
    8. XM_039085532.2XP_038941460.1  active breakpoint cluster region-related protein isoform X6

      UniProtKB/TrEMBL
      A0A8I6GI56
      Related
      ENSRNOP00000090388.1, ENSRNOT00000105253.2
      Conserved Domains (4) summary
      cd08686
      Location:288408
      C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
      cd04387
      Location:427622
      RhoGAP_Bcr; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr ...
      cd13366
      Location:59242
      PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain
      cl02571
      Location:1764
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    9. XM_039085533.2XP_038941461.1  active breakpoint cluster region-related protein isoform X7

      Conserved Domains (2) summary
      cd04387
      Location:102297
      RhoGAP_Bcr; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr ...
      cl14603
      Location:5583
      C2; C2 domain
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