Supt16h SPT16 homolog, facilitates chromatin remodeling subunit [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Supt16hprovided by RGD
Official Full Name: SPT16 homolog, facilitates chromatin remodeling subunitprovided by RGD
Primary source: RGD:1310032
See related: EnsemblRapid:ENSRNOG00000011953 AllianceGenome:RGD:1310032
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable nucleosome binding activity. Predicted to be involved in nucleosome disassembly and transcription elongation by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of FACT complex. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with dysmorphic facies and thin corpus callosum. Orthologous to human SUPT16H (SPT16 homolog, facilitates chromatin remodeling subunit). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 368.6), Spleen (RPKM 305.5) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 15p14

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (27341196..27378314, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (24867697..24904818, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (28574841..28611959, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

RH138387 (e-PCR)
- UniSTS:220474

AA997586 (e-PCR)
- UniSTS:248418

WI-14045 (e-PCR)
- UniSTS:39614

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables nucleosome binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in biological_process	ND No biological Data available more info
involved_in nucleosome disassembly	ISO Inferred from Sequence Orthology more info
involved_in transcription elongation by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of FACT complex	IBA Inferred from Biological aspect of Ancestor more info
part_of FACT complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: FACT complex subunit SPT16

Names: suppressor of Ty 16 homolog

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107261.1 → NP_001100731.1 FACT complex subunit SPT16

See identical proteins and their annotated locations for NP_001100731.1

Status: PROVISIONAL

Source sequence(s)

CH474040

UniProtKB/TrEMBL

A0A8I5ZJ57, A0A8I6GJV6, A6KEG6

Related

ENSRNOP00000016288.5, ENSRNOT00000016288.7

Conserved Domains (5) summary

COG5406
Location:5 → 1001

COG5406; Nucleosome binding factor SPN, SPT16 subunit [Transcription, Replication, recombination and repair, Chromatin structure and dynamics]

cd01091
Location:180 → 420

CDC68-like; Related to aminopeptidase P and aminopeptidase M, a member of this domain family is present in cell division control protein 68, a transcription factor.

pfam08512
Location:813 → 889

Rtt106; Histone chaperone Rttp106-like

pfam08644
Location:534 → 689

SPT16; FACT complex subunit (SPT16/CDC68)

pfam14826
Location:5 → 166

FACT-Spt16_Nlob; FACT complex subunit SPT16 N-terminal lobe domain