Abhd4 abhydrolase domain containing 4, N-acyl phospholipase B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Abhd4provided by RGD
Official Full Name: abhydrolase domain containing 4, N-acyl phospholipase Bprovided by RGD
Primary source: RGD:1311858
See related: EnsemblRapid:ENSRNOG00000009244 AllianceGenome:RGD:1311858
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Abh4
Summary: Predicted to enable lysophosphatidic acid acyltransferase activity and lysophospholipase activity. Predicted to be involved in N-acylphosphatidylethanolamine metabolic process; lipid homeostasis; and phosphatidic acid biosynthetic process. Predicted to act upstream of or within N-acylethanolamine metabolic process. Predicted to be active in lipid droplet and mitochondrion. Orthologous to human ABHD4 (abhydrolase domain containing 4, N-acyl phospholipase B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 1021.0), Testes (RPKM 459.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p13

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (31674090..31686051)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (27697384..27716013)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (32888233..32906861)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lysophospholipase/phospholipase B (EC 3.1.1.5) specific for N-acyl phosphatidylethanolamine (NAPE) suggesting a role in the biosynthesis of N-acyl ethanolamines including the endocannabinoid anandamide.
Title: Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for alpha/beta-hydrolase 4 in this pathway.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables lysophosphatidic acid acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables lysophospholipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables lysophospholipase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within N-acylethanolamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in N-acylphosphatidylethanolamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in lipid homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidic acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in lipid droplet	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: (Lyso)-N-acylphosphatidylethanolamine lipase

Names: abhydrolase domain-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108866.1 → NP_001102336.1 (Lyso)-N-acylphosphatidylethanolamine lipase

See identical proteins and their annotated locations for NP_001102336.1

Status: PROVISIONAL

Source sequence(s)

CH474049

UniProtKB/TrEMBL

A0A8I6ADA8, A6KGS0, D3ZAW4

Related

ENSRNOP00000012837.5, ENSRNOT00000012837.9

Conserved Domains (1) summary

PLN02894
Location:24 → 351

PLN02894; hydrolase, alpha/beta fold family protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

31674090..31686051

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039093545.2 → XP_038949473.1 (Lyso)-N-acylphosphatidylethanolamine lipase isoform X2

Conserved Domains (1) summary

PLN02894
Location:25 → 175

PLN02894; hydrolase, alpha/beta fold family protein
XM_006251996.5 → XP_006252058.1 (Lyso)-N-acylphosphatidylethanolamine lipase isoform X1

See identical proteins and their annotated locations for XP_006252058.1

UniProtKB/TrEMBL

A0A8I6ADA8

Conserved Domains (2) summary

COG0596
Location:43 → 312

MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

cl21494
Location:30 → 145

Abhydrolase; alpha/beta hydrolases