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    Aoah acyloxyacyl hydrolase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498757, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Aoahprovided by RGD
    Official Full Name
    acyloxyacyl hydrolaseprovided by RGD
    Primary source
    RGD:1560514
    See related
    EnsemblRapid:ENSRNOG00000054964 AllianceGenome:RGD:1560514
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560514
    Summary
    Predicted to enable acyloxyacyl hydrolase activity and calcium ion binding activity. Predicted to be involved in fatty acid metabolic process; lipopolysaccharide catabolic process; and negative regulation of inflammatory response. Predicted to act upstream of or within lipopolysaccharide metabolic process. Orthologous to human AOAH (acyloxyacyl hydrolase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 76.4), Kidney (RPKM 55.2) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Aoah in Genome Data Viewer
    Location:
    17q11
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (48503812..48745161, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (43808110..44049458, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (45872414..46115026, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene sorbitol dehydrogenase pseudogene Neighboring gene olfactory receptor family 2 subfamily P member 2 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene small nucleolar RNA SNORA17 Neighboring gene FUS RNA binding protein, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of acyloxyacyl hydrolase, a lipopolysaccharide-detoxifying enzyme, in the murine urinary tract. Feulner JA, et al. Infect Immun, 2004 Jun. PMID 15155618, Free PMC Article
    2. Expression and characterization of recombinant human acyloxyacyl hydrolase, a leukocyte enzyme that deacylates bacterial lipopolysaccharides. Hagen FS, et al. Biochemistry, 1991 Aug 27. PMID 1883828
    3. Crystal structure of the mammalian lipopolysaccharide detoxifier. Gorelik A, et al. Proc Natl Acad Sci U S A, 2018 Jan 30. PMID 29343645, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables acyloxyacyl hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acyloxyacyl hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipopolysaccharide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipopolysaccharide catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lipopolysaccharide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    acyloxyacyl hydrolase
    Names
    acyloxyacyl hydrolase (neutrophil)
    NP_001178869.1
    XP_038951942.1
    XP_038951944.1
    XP_038951945.1
    XP_038951946.1
    XP_038951947.1
    XP_038951948.1
    XP_038951949.1
    XP_038951951.1
    XP_063132763.1
    XP_063132764.1
    XP_063132765.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191940.2 → NP_001178869.1  acyloxyacyl hydrolase precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A0G2K753, A6KN60
      Related
      ENSRNOP00000074067.3, ENSRNOT00000087838.3
      Conserved Domains (4) summary
      smart00741
      Location:40 → 113
      SapB; Saposin (B) Domains
      cd01826
      Location:243 → 545
      acyloxyacyl_hydrolase_like; Acyloxyacyl-hydrolase like subfamily of the SGNH-hydrolase family. Acyloxyacyl-hydrolase is a leukocyte-secreted enzyme that deacetylates bacterial lipopolysaccharides.
      pfam03489
      Location:82 → 113
      SapB_2; Saposin-like type B, region 2
      pfam11617
      Location:204 → 232
      Cu-binding_MopE; Putative metal-binding motif

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      48503812..48745161 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096014.2 → XP_038951942.1  acyloxyacyl hydrolase isoform X1

      UniProtKB/TrEMBL
      A6KN60
      Conserved Domains (3) summary
      smart00741
      Location:40 → 113
      SapB; Saposin (B) Domains
      cd01826
      Location:223 → 525
      acyloxyacyl_hydrolase_like; Acyloxyacyl-hydrolase like subfamily of the SGNH-hydrolase family. Acyloxyacyl-hydrolase is a leukocyte-secreted enzyme that deacetylates bacterial lipopolysaccharides.
      pfam11617
      Location:184 → 212
      Cu-binding_MopE; Putative metal-binding motif

    2. XM_039096016.2 → XP_038951944.1  acyloxyacyl hydrolase isoform X2

      UniProtKB/TrEMBL
      A6KN60
      Related
      ENSRNOP00000100720.1, ENSRNOT00000162138.1
      Conserved Domains (3) summary
      smart00741
      Location:40 → 113
      SapB; Saposin (B) Domains
      pfam11617
      Location:204 → 232
      Cu-binding_MopE; Putative metal-binding motif
      cl01053
      Location:243 → 505
      SGNH_hydrolase; or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the typical ...

    3. XM_039096017.2 → XP_038951945.1  acyloxyacyl hydrolase isoform X3

      UniProtKB/TrEMBL
      A6KN60
      Conserved Domains (3) summary
      smart00741
      Location:1 → 49
      SapB; Saposin (B) Domains
      cd01826
      Location:179 → 481
      acyloxyacyl_hydrolase_like; Acyloxyacyl-hydrolase like subfamily of the SGNH-hydrolase family. Acyloxyacyl-hydrolase is a leukocyte-secreted enzyme that deacetylates bacterial lipopolysaccharides.
      pfam11617
      Location:140 → 168
      Cu-binding_MopE; Putative metal-binding motif

    4. XM_039096018.2 → XP_038951946.1  acyloxyacyl hydrolase isoform X4

      UniProtKB/TrEMBL
      A6KN60
      Conserved Domains (2) summary
      cd01826
      Location:143 → 445
      acyloxyacyl_hydrolase_like; Acyloxyacyl-hydrolase like subfamily of the SGNH-hydrolase family. Acyloxyacyl-hydrolase is a leukocyte-secreted enzyme that deacetylates bacterial lipopolysaccharides.
      pfam11617
      Location:104 → 132
      Cu-binding_MopE; Putative metal-binding motif

    5. XM_063276693.1 → XP_063132763.1  acyloxyacyl hydrolase isoform X5

    6. XM_039096019.2 → XP_038951947.1  acyloxyacyl hydrolase isoform X4

      UniProtKB/TrEMBL
      A6KN60
      Conserved Domains (2) summary
      cd01826
      Location:143 → 445
      acyloxyacyl_hydrolase_like; Acyloxyacyl-hydrolase like subfamily of the SGNH-hydrolase family. Acyloxyacyl-hydrolase is a leukocyte-secreted enzyme that deacetylates bacterial lipopolysaccharides.
      pfam11617
      Location:104 → 132
      Cu-binding_MopE; Putative metal-binding motif

    7. XM_063276695.1 → XP_063132765.1  acyloxyacyl hydrolase isoform X7

    8. XM_063276694.1 → XP_063132764.1  acyloxyacyl hydrolase isoform X7

    9. XM_039096023.2 → XP_038951951.1  acyloxyacyl hydrolase isoform X9

      Conserved Domains (1) summary
      cl01053
      Location:1 → 267
      SGNH_hydrolase; or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the typical ...

    10. XM_039096021.2 → XP_038951949.1  acyloxyacyl hydrolase isoform X8

      Conserved Domains (3) summary
      smart00741
      Location:40 → 113
      SapB; Saposin (B) Domains
      pfam11617
      Location:204 → 232
      Cu-binding_MopE; Putative metal-binding motif
      cl01053
      Location:243 → 339
      SGNH_hydrolase; or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the typical ...

    11. XM_039096020.2 → XP_038951948.1  acyloxyacyl hydrolase isoform X6

      Conserved Domains (3) summary
      smart00741
      Location:40 → 113
      SapB; Saposin (B) Domains
      pfam11617
      Location:204 → 232
      Cu-binding_MopE; Putative metal-binding motif
      cl01053
      Location:243 → 339
      SGNH_hydrolase; or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the typical ...

    RNA

    1. XR_005495324.2 RNA Sequence

    2. XR_005495320.2 RNA Sequence

    3. XR_005495322.2 RNA Sequence

    4. XR_005495325.2 RNA Sequence

    5. XR_005495323.2 RNA Sequence

    6. XR_005495321.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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