Septin1 septin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Septin1provided by RGD
Official Full Name: septin 1provided by RGD
Primary source: RGD:1307216
See related: EnsemblRapid:ENSRNOG00000017804 AllianceGenome:RGD:1307216
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sept1
Summary: Predicted to enable GTPase activity; identical protein binding activity; and molecular adaptor activity. Predicted to be involved in cytoskeleton-dependent cytokinesis; protein localization; and regulation of exocytosis. Predicted to act upstream of or within meiotic metaphase chromosome alignment and spindle assembly involved in female meiosis. Predicted to be located in meiotic spindle and midbody. Predicted to be part of septin complex. Predicted to be active in cell division site; cytoskeleton; and synaptic vesicle. Orthologous to human SEPTIN1 (septin 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 1180.9), Spleen (RPKM 395.5) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 1q37

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (191263200..191267086, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (181832700..181836566, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (198658744..198662610, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH131023 (e-PCR)
- UniSTS:214306

BE102672 (e-PCR)
- UniSTS:244304

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cytoskeleton-dependent cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within meiotic metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of exocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within spindle assembly involved in female meiosis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cell division site	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in meiotic spindle	ISO Inferred from Sequence Orthology more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	ISO Inferred from Sequence Orthology more info
part_of septin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in septin ring	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: septin-1

NP_001012478.1

EC 3.1.5.1

XP_063142351.1

EC 3.1.5.1

XP_063142353.1

EC 3.1.5.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012460.1 → NP_001012478.1 septin-1

See identical proteins and their annotated locations for NP_001012478.1

Status: PROVISIONAL

Source sequence(s)

BC089897

UniProtKB/Swiss-Prot

Q5EB96

UniProtKB/TrEMBL

A6I9N1, A6I9N2

Related

ENSRNOP00000051893.2, ENSRNOT00000055012.4

Conserved Domains (2) summary

COG5019
Location:5 → 348

CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

pfam00735
Location:22 → 295

Septin; Septin