Orai3 ORAI calcium release-activated calcium modulator 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Orai3provided by RGD
Official Full Name: ORAI calcium release-activated calcium modulator 3provided by RGD
Primary source: RGD:1306538
See related: EnsemblRapid:ENSRNOG00000039730 AllianceGenome:RGD:1306538
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CRACM3; RGD1306538
Summary: Predicted to enable store-operated calcium channel activity. Predicted to be involved in store-operated calcium entry. Predicted to be located in plasma membrane. Predicted to be active in membrane. Orthologous to human ORAI3 (ORAI calcium release-activated calcium modulator 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 74.5), Kidney (RPKM 61.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q37

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (191811671..191816530)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (182381196..182386055)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (199217504..199222363)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulation of Orai Channels Contributes to Aging-Related Vascular Alterations in Rat Coronary Arteries.
Title: Upregulation of Orai Channels Contributes to Aging-Related Vascular Alterations in Rat Coronary Arteries.
Role of Orai3-Mediated Store-Operated Calcium Entry in Radiation-Induced Brain Microvascular Endothelial Cell Injury.
Title: Role of Orai3-Mediated Store-Operated Calcium Entry in Radiation-Induced Brain Microvascular Endothelial Cell Injury.
Orai3 exacerbates apoptosis of lens epithelial cells by disrupting Ca(2+) homeostasis in diabetic cataract.
Title: Orai3 exacerbates apoptosis of lens epithelial cells by disrupting Ca(2+) homeostasis in diabetic cataract.
Cardiac inflammatory CD11b/c cells exert a protective role in hypertrophied cardiomyocyte by promoting TNFR2- and Orai3- dependent signaling.
Title: Cardiac inflammatory CD11b/c cells exert a protective role in hypertrophied cardiomyocyte by promoting TNFR(2)- and Orai3- dependent signaling.
CRACM3 affects cell exocytosis by influencing the activity-dependent fusion pore open time. Extracellular loop 3 and the C-terminus of CRACM3 are critical for binding the N-peptide of syntaxin-4.
Title: CRACM3 regulates the stability of non-excitable exocytotic vesicle fusion pores in a Ca(2+)-independent manner via molecular interaction with syntaxin4.
Cardiac Orai3 is the essential partner of STIM1 and drives voltage-independent Ca(2+) entry in adult cardiomyocytes. Arachidonic acid-activated currents supported by Orai3 are present in adult cardiomyocytes and increased during hypertrophy.
Title: Emergence of Orai3 activity during cardiac hypertrophy.
LTC4S and Orai3 altered Akt signaling to promote VSMC migration and neointima formation.
Title: Leukotriene-C4 synthase, a critical enzyme in the activation of store-independent Orai1/Orai3 channels, is required for neointimal hyperplasia.
The second coiled-coil domain of STIM1 is required for coupling to either Orai3 or Orai3/Orai1 channels.
Title: Mechanisms of STIM1 activation of store-independent leukotriene C4-regulated Ca2+ channels.
Orai channels are activated by different agonists/pathways and uncover a mechanism whereby leukotrieneC4 acts through hitherto unknown intracrine mode to elicit store-independent Ca(2+) signaling that promotes vascular occlusive disease.
Title: Store-independent Orai1/3 channels activated by intracrine leukotriene C4: role in neointimal hyperplasia.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables store-operated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables store-operated calcium channel activity	IEA Inferred from Electronic Annotation more info
enables store-operated calcium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in store-operated calcium entry	IBA Inferred from Biological aspect of Ancestor more info
involved_in store-operated calcium entry	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within store-operated calcium entry	ISO Inferred from Sequence Orthology more info
involved_in store-operated calcium entry	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein orai-3

Names: calcium release-activated calcium modulator 3 protein; transmembrane protein 142C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.