Rala RAS like proto-oncogene A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ralaprovided by RGD
Official Full Name: RAS like proto-oncogene Aprovided by RGD
Primary source: RGD:619851
See related: EnsemblRapid:ENSRNOG00000013454 AllianceGenome:RGD:619851
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including Edg-2 lysophosphatidic acid receptor binding activity; enzyme binding activity; and guanyl ribonucleotide binding activity. Involved in regulation of postsynaptic neurotransmitter receptor internalization. Is active in Schaffer collateral - CA1 synapse and synaptic membrane. Orthologous to human RALA (RAS like proto-oncogene A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 118.4), Brain (RPKM 109.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17q11

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (51787682..51840738)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (47092163..47145192)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (49676073..49729133)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

specific activation of Rap1B contributes to neuronal polarization via interaction with RalA and Nore1A in addition to PI3-kinase.
Title: Longest neurite-specific activation of Rap1B in hippocampal neurons contributes to polarity formation through RalA and Nore1A in addition to PI3-kinase.
RalA modulates insulin release by binding to auxiliary calcium channel subunits on the insulin granules.
Title: RalA GTPase tethers insulin granules to L- and R-type calcium channels through binding α2 δ-1 subunit.
RalA plays a pivotal role also in Rac1-mediated GLUT4 translocation in muscle cells.
Title: Role of RalA downstream of Rac1 in insulin-dependent glucose uptake in muscle cells.
Demonstrated that the PH-PxxP domain of RalGPS2 inhibits RalA activation inducing PC12 differentiation redirecting NGF signal to MAPK pathway, and that this domain is involved in the actin remodelling which is necessary for neurites elongation.
Title: The PH-PxxP domain of RalGPS2 promotes PC12 cells differentiation acting as a dominant negative for RalA GTPase activation.
RalA activation elicited by the exchange factor RalGDS in response to a rise in intracellular Ca2+ and cAMP controls hormone release from pancreatic beta-cells
Title: The GTPase RalA regulates different steps of the secretory process in pancreatic beta-cells.
RalA and the exocyst complex influence neuronal polarity through PAR-3 and aPKC.
Title: RalA and the exocyst complex influence neuronal polarity through PAR-3 and aPKC.
Localization of Exocyst and, by extension, targeting of Exocyst-dependent cargo, is dependent on Ral GTPases, which control association between Sec5 and paxillin.
Title: Ral-regulated interaction between Sec5 and paxillin targets Exocyst to focal complexes during cell migration.
RalA is a critical component in biphasic insulin release from pancreatic beta cells
Title: The RalA GTPase is a central regulator of insulin exocytosis from pancreatic islet beta cells.
The two Ral isoforms, RalA and -B, promote branching through distinct pathways, involving the exocyst complex and phospholipase D, respectively.
Title: Ral GTPases regulate neurite branching through GAP-43 and the exocyst complex.
Our results indicate that endogenous RalA and RalB function specifically as GTP sensors for the GTP-dependent exocytosis of dense core vesicles.
Title: RalA and RalB function as the critical GTP sensors for GTP-dependent exocytosis.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Rasl1 (e-PCR), detects polymorphism
- UniSTS:144329

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables Edg-2 lysophosphatidic acid receptor binding	ISO Inferred from Sequence Orthology more info
enables Edg-2 lysophosphatidic acid receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GDP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	NAS Non-traceable Author Statement more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables myosin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in establishment of protein localization to mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization to mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in membrane raft localization	ISO Inferred from Sequence Orthology more info
involved_in membrane raft localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in neural tube closure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial fission	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial fission	ISS Inferred from Sequence or Structural Similarity more info
involved_in receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of exocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of exocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of postsynaptic neurotransmitter receptor internalization	EXP Inferred from Experiment more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor internalization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor internalization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Flemming body	IEA Inferred from Electronic Annotation more info
is_active_in Schaffer collateral - CA1 synapse	EXP Inferred from Experiment more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cleavage furrow	ISO Inferred from Sequence Orthology more info
located_in cleavage furrow	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ras-related protein Ral-A

Names: RALA Ras like proto-oncogene A; v-ral simian leukemia viral oncogene homolog A (ras related)

NP_001401109.1

EC 3.6.5.2

NP_112355.1

EC 3.6.5.2

XP_038952038.1

EC 3.6.5.2

XP_038952040.1

EC 3.6.5.2

XP_063132843.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001414180.2 → NP_001401109.1 ras-related protein Ral-A

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/Swiss-Prot

P63322

UniProtKB/TrEMBL

A0A8L2Q942, A6K9A2

Related

ENSRNOP00000090376.2, ENSRNOT00000102020.2
NM_031093.4 → NP_112355.1 ras-related protein Ral-A

See identical proteins and their annotated locations for NP_112355.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/Swiss-Prot

P63322

UniProtKB/TrEMBL

A0A8L2Q942, A6K9A2

Related

ENSRNOP00000018190.4, ENSRNOT00000018190.6

Conserved Domains (1) summary

cd04139
Location:15 → 177

RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

51787682..51840738

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063276773.1 → XP_063132843.1 ras-related protein Ral-A isoform X2
XM_039096112.2 → XP_038952040.1 ras-related protein Ral-A isoform X1

UniProtKB/Swiss-Prot

P63322

UniProtKB/TrEMBL

A0A8L2Q942, A6K9A2

Conserved Domains (1) summary

cd04139
Location:15 → 177

RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB
XM_039096110.2 → XP_038952038.1 ras-related protein Ral-A isoform X1

UniProtKB/Swiss-Prot

P63322

UniProtKB/TrEMBL

A0A8L2Q942, A6K9A2

Conserved Domains (1) summary

cd04139
Location:15 → 177

RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB