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    Ano4 anoctamin 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299714, updated on 9-Dec-2024

    Summary

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    Symbol
    Ano4provided by RGD
    Full Name
    anoctamin 4provided by RGD
    Primary source
    RGD:1310252
    See related
    EnsemblRapid:ENSRNOG00000006841 AllianceGenome:RGD:1310252
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tmem16d
    Summary
    Predicted to enable intracellularly calcium-gated chloride channel activity and phospholipid scramblase activity. Predicted to be involved in chloride transmembrane transport. Predicted to act upstream of or within calcium activated phospholipid scrambling and establishment of localization in cell. Predicted to be active in plasma membrane. Orthologous to human ANO4 (anoctamin 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 54.8), Uterus (RPKM 44.8) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ano4 in Genome Data Viewer
    Location:
    7q13
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (25216389..25625811, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (23329015..23738423, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (29492017..30025587, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene UTP20 small subunit processome component Neighboring gene solute carrier family 5 member 8 Neighboring gene peptidyl-prolyl cis-trans isomerase A-like Neighboring gene 60S ribosomal protein L9 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Anoctamins are a family of Ca2+-activated Cl- channels. Tian Y, et al. J Cell Sci, 2012 Nov 1. PMID 22946059
    2. ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins. Duran C, et al. Am J Physiol Cell Physiol, 2012 Feb 1. PMID 22075693, Free PMC Article
    3. Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members. Suzuki J, et al. J Biol Chem, 2013 May 10. PMID 23532839, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables intracellularly calcium-gated chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables intracellularly calcium-gated chloride channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables intracellularly calcium-gated chloride channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipid scramblase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium activated galactosylceramide scrambling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within calcium activated phosphatidylcholine scrambling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within calcium activated phosphatidylserine scrambling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within establishment of localization in cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    anoctamin-4
    Names
    chromosome alignment-maintaining phosphoprotein 1-like
    transmembrane protein 16D (eight membrane-spanning domains)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106778.2 → NP_001100248.1  anoctamin-4 isoform 2

      See identical proteins and their annotated locations for NP_001100248.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6IFQ7, F1M4U7
      Related
      ENSRNOP00000009084.6, ENSRNOT00000009084.9
      Conserved Domains (1) summary
      pfam04547
      Location:31 → 534
      Anoctamin; Calcium-activated chloride channel

    2. NM_001395725.1 → NP_001382654.1  anoctamin-4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000007
      Related
      ENSRNOP00000079757.2, ENSRNOT00000109574.2
      Conserved Domains (2) summary
      pfam04547
      Location:339 → 920
      Anoctamin; Calcium-activated chloride channel
      pfam16178
      Location:111 → 336
      Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      25216389..25625811 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078690.2 → XP_038934618.1  anoctamin-4 isoform X4

      Conserved Domains (2) summary
      pfam04547
      Location:494 → 1075
      Anoctamin; Calcium-activated chloride channel
      pfam16178
      Location:310 → 491
      Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin

    2. XM_039078688.2 → XP_038934616.1  anoctamin-4 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AKC4
      Conserved Domains (2) summary
      pfam04547
      Location:523 → 1104
      Anoctamin; Calcium-activated chloride channel
      pfam16178
      Location:310 → 520
      Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin

    3. XM_063263196.1 → XP_063119266.1  anoctamin-4 isoform X3

      Related
      ENSRNOP00000089175.2, ENSRNOT00000117276.2

    4. XM_017594726.3 → XP_017450215.2  anoctamin-4 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K0I0
      Related
      ENSRNOP00000071454.2, ENSRNOT00000089269.3
      Conserved Domains (2) summary
      pfam04547
      Location:538 → 1119
      Anoctamin; Calcium-activated chloride channel
      pfam16178
      Location:310 → 535
      Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin

    5. XM_063263197.1 → XP_063119267.1  anoctamin-4 isoform X6

      Related
      ENSRNOP00000107992.1, ENSRNOT00000133879.1

    6. XM_063263198.1 → XP_063119268.1  anoctamin-4 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZNA1

    7. XM_017594725.3 → XP_017450214.1  anoctamin-4 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K0I0
      Conserved Domains (2) summary
      pfam04547
      Location:339 → 920
      Anoctamin; Calcium-activated chloride channel
      pfam16178
      Location:111 → 336
      Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin

    8. XM_039078692.2 → XP_038934620.1  anoctamin-4 isoform X9

      Conserved Domains (2) summary
      pfam04547
      Location:124 → 705
      Anoctamin; Calcium-activated chloride channel
      pfam16178
      Location:28 → 121
      Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin

    9. XM_008765230.4 → XP_008763452.1  anoctamin-4 isoform X8

      Conserved Domains (2) summary
      pfam04547
      Location:168 → 749
      Anoctamin; Calcium-activated chloride channel
      pfam16178
      Location:26 → 165
      Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin

    10. XM_039078691.2 → XP_038934619.1  anoctamin-4 isoform X8

      Conserved Domains (2) summary
      pfam04547
      Location:168 → 749
      Anoctamin; Calcium-activated chloride channel
      pfam16178
      Location:26 → 165
      Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin
    Nucleotide Protein Strain
    Heading Accession and Version

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