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    Ndufa9 NADH:ubiquinone oxidoreductase subunit A9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362440, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ndufa9provided by RGD
    Official Full Name
    NADH:ubiquinone oxidoreductase subunit A9provided by RGD
    Primary source
    RGD:1307307
    See related
    EnsemblRapid:ENSRNOG00000061684 AllianceGenome:RGD:1307307
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable NADH dehydrogenase activity. Involved in response to glucose. Predicted to be located in mitochondrial inner membrane and mitochondrial matrix. Predicted to be part of respiratory chain complex I. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 26. Orthologous to human NDUFA9 (NADH:ubiquinone oxidoreductase subunit A9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 2222.8), Muscle (RPKM 1592.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ndufa9 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (161345398..161374188, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (159659242..159688034, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (159371263..159399636, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily A member 6 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 8 Neighboring gene uncharacterized LOC134486843 Neighboring gene A-kinase anchoring protein 3 Neighboring gene dual specificity tyrosine phosphorylation regulated kinase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Increased enzymatic O-GlcNAcylation of mitochondrial proteins impairs mitochondrial function in cardiac myocytes exposed to high glucose. Hu Y, et al. J Biol Chem, 2009 Jan 2. PMID 19004814, Free PMC Article
    2. Construction and evaluation of a hncDNA library of human 12p transcribed sequences derived from a somatic cell hybrid. Baens M, et al. Genomics, 1993 Apr. PMID 8486360
    3. Mice with mitochondrial complex I deficiency develop a fatal encephalomyopathy. Kruse SE, et al. Cell Metab, 2008 Apr. PMID 18396137, Free PMC Article
    4. CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis. Lin R, et al. Mol Cell, 2017 Oct 5. PMID 28985504
    5. Partial complex I deficiency due to the CNS conditional ablation of Ndufa5 results in a mild chronic encephalopathy but no increase in oxidative damage. Peralta S, et al. Hum Mol Genet, 2014 Mar 15. PMID 24154540, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NADH dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADH dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in circadian rhythm IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in circadian rhythm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to glucose IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in ubiquinone biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of respiratory chain complex I IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex I ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
    Names
    CI-39kD
    NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9
    NADH-ubiquinone oxidoreductase 39 kDa subunit
    complex I-39kD
    sperm flagella protein 3
    NP_001094222.1
    XP_006237562.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100752.1 → NP_001094222.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

      See identical proteins and their annotated locations for NP_001094222.1

      Status: PROVISIONAL

      Source sequence(s)
      BC168777
      UniProtKB/Swiss-Prot
      B5DER7, Q5BK63
      UniProtKB/TrEMBL
      A0A8L2R6R3
      Related
      ENSRNOP00000085680.2, ENSRNOT00000097650.2
      Conserved Domains (1) summary
      cd05271
      Location:54 → 326
      NDUFA9_like_SDR_a; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      161345398..161374188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237500.3 → XP_006237562.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8L2R6R3
      Conserved Domains (2) summary
      cd05271
      Location:50 → 322
      NDUFA9_like_SDR_a; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs
      pfam01370
      Location:52 → 259
      Epimerase; NAD dependent epimerase/dehydratase family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BK63.2 GenPept UniProtKB/Swiss-Prot:Q5BK63

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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