Thpol1 thrombopoietin like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Thpol1provided by RGD
Official Full Name: thrombopoietin like 1provided by RGD
Primary source: RGD:11455920
See related: EnsemblRapid:ENSRNOG00000046850 AllianceGenome:RGD:11455920
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Thpo
Summary: Predicted to enable cytokine activity and hormone activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; megakaryocyte development; and positive regulation of intracellular signal transduction. Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in aplastic anemia; congenital amegakaryocytic thrombocytopenia 2; essential thrombocythemia; thrombocytopenia; and thrombocytosis. Orthologous to human THPO (thrombopoietin). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 28.0), Liver (RPKM 26.2) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q23

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (93687033..93696293)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (80182590..80188927)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (82845676..82853439)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fourteen channels of thrombopoietin signaling pathway participated in regulating hepatocyte activation during rat liver regeneration.
Title: Thrombopoietin Signaling Pathway Regulates Hepatocyte Activation in Rat Liver Regeneration.
The data suggest a potential role of thrombopoietin (TPO) as a physiological regulator of coronary flow. By acting on specific receptors present on endothelial cells, TPO may induce PI3K/Akt-dependent eNOS phosphorylation and NO release.
Title: A novel role of thrombopoietin as a physiological modulator of coronary flow.
cell-type-specific modulation of Tpo mRNA expression by inflammation in brain-derived cells
Title: Inflammation stimulates thrombopoietin (Tpo) expression in rat brain-derived microvascular endothelial cells, but suppresses Tpo in astrocytes and microglia.
TPO negatively modulates cardiac inotropy in vitro and contributes to the myocardial depressing activity of septic shock serum
Title: Thrombopoietin modulates cardiac contractility in vitro and contributes to myocardial depressing activity of septic shock serum.
TPO via activation of its receptor-bound JAK2 delays the NGF-dependent acquisition of neuronal phenotype and decreases neuronal survival by suppressing NGF-induced ERK activity
Title: Thrombopoietin inhibits nerve growth factor-induced neuronal differentiation and ERK signalling.
LPS-treated rats showed a significant increase in hepatic TPO mRNA concentration. The ratio of TPO to GAPDH mRNA was 3.5 +/- 0.6% in the livers of control rats and 8.3 +/- 2.0% in the livers of LPS-treated rats (mean +/- SD).
Title: Hepatic thrombopoietin mRNA is increased in acute inflammation.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables hormone activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway via STAT	IEA Inferred from Electronic Annotation more info
involved_in megakaryocyte development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of hematopoietic stem cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in thrombopoietin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: thrombopoietin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031133.2 → NP_112395.1 thrombopoietin precursor

See identical proteins and their annotated locations for NP_112395.1

Status: PROVISIONAL

Source sequence(s)

D32207

UniProtKB/Swiss-Prot

P49745

UniProtKB/TrEMBL

A0A8L2QZ16, A6JS79

Related

ENSRNOP00000111405.1, ENSRNOT00000145928.1

Conserved Domains (1) summary

pfam00758
Location:25 → 175

EPO_TPO; Erythropoietin/thrombopoietin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

93687033..93696293

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039088637.2 → XP_038944565.1 thrombopoietin isoform X2

Conserved Domains (1) summary

pfam00758
Location:177 → 293

EPO_TPO; Erythropoietin/thrombopoietin
XM_006248553.5 → XP_006248615.1 thrombopoietin isoform X1

Related

ENSRNOP00000067269.3, ENSRNOT00000072402.3

Conserved Domains (1) summary

pfam00758
Location:177 → 323

EPO_TPO; Erythropoietin/thrombopoietin