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    Hbb-b1 hemoglobin, beta adult major chain [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361619, updated on 27-Dec-2024

    Summary

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    Symbol
    Hbb-b1provided by RGD
    Full Name
    hemoglobin, beta adult major chainprovided by RGD
    Primary source
    RGD:1595848
    See related
    AllianceGenome:RGD:1595848
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Glna1
    Summary
    Predicted to enable several functions, including heme binding activity; oxygen binding activity; and oxygen carrier activity. Predicted to be involved in oxygen transport. Predicted to be part of hemoglobin complex. Orthologous to human HBD (hemoglobin subunit delta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 79181.0), Lung (RPKM 19340.1) and 1 other tissue See more
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    Genomic context

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    See Hbb-b1 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (167636064..167643577, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (158224175..158231675, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (168945531..168953023)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 52 subfamily Z member 1 Neighboring gene hemoglobin, beta adult s chain Neighboring gene hemoglobin subunit beta like 1 Neighboring gene hemoglobin, beta adult minor chain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. [Isolation and characterization of three rat adult type beta-globin genes]. Inokuchi N. Nihon Ika Daigaku Zasshi, 1994 Nov. PMID 7829656
    2. Genomic organization and characterization of a three-gene rat adult beta-globin haplotype. Au DM, et al. Gene, 1995 Nov 20. PMID 8522187
    3. Characterization of two rat globin cDNA clones. Crkvenjakov R, et al. Hemoglobin, 1984. PMID 6098570
    4. Origin of rat beta-globin haplotypes containing three and five genes. Paunesku T, et al. Mol Biol Evol, 1990 Sep. PMID 2263193
    5. The novel testicular enrichment protein Cfap58 is required for Notch-associated ciliogenesis. Li ZZ, et al. Biosci Rep, 2020 Jan 31. PMID 31904090, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC72973

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxygen binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxygen carrier activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in oxygen transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of hemoglobin complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    hemoglobin, beta adult major chain
    Names
    beta-glo
    globin a1
    hemoglobin beta-chain
    hemoglobin subunit beta-2-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198776.2 → NP_942071.2  hemoglobin, beta adult major chain

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6AUL4, Q62669
      Conserved Domains (1) summary
      cd08925
      Location:8 → 146
      Hb-beta-like; Hemoglobin beta, gamma, delta, epsilon, and related Hb subunits

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      167636064..167643577 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229913.5 → XP_006229975.3  hemoglobin, beta adult major chain isoform X1

      Conserved Domains (1) summary
      cl21461
      Location:8 → 107
      Globin-like; Globin-like protein superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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