Taar1 trace-amine-associated receptor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Taar1provided by RGD
Official Full Name: trace-amine-associated receptor 1provided by RGD
Primary source: RGD:621621
See related: EnsemblRapid:ENSRNOG00000016073 AllianceGenome:RGD:621621
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tar1; Trar1; taR-1
Summary: Predicted to enable trace-amine receptor activity. Involved in positive regulation of cAMP/PKA signal transduction. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endomembrane system and plasma membrane. Orthologous to human TAAR1 (trace amine associated receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 1p12

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (23336978..23337976, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (21517742..21518740, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (22595477..22596475, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Trace amine-associated receptor 1 modulates motor hyperactivity, cognition, and anxiety-like behavior in an animal model of ADHD.
Title: Trace amine-associated receptor 1 modulates motor hyperactivity, cognition, and anxiety-like behavior in an animal model of ADHD.
Pretreatment with the trace amine-associate receptor 1 (TAAR1) antagonist EPPTB (5mg/kg, i.v.) blocked the inhibitory effect of LSD on VTA DA neurons.
Title: The hallucinogen d-lysergic diethylamide (LSD) decreases dopamine firing activity through 5-HT(1A), D(2) and TAAR(1) receptors.
TAAR1 in different subregions of the mesocorticolimbic system contributes to reinstatement of cocaine-seeking behavior.
Title: Role of TAAR1 within the Subregions of the Mesocorticolimbic Dopaminergic System in Cocaine-Seeking Behavior.
Results demonstrate that betaArr2 signaling may be an important pathway for TAAR1 function and that the activation of the TAAR1-D2R complex negatively modulates GSK3b signaling
Title: Trace amine-associated receptor 1 activation silences GSK3β signaling of TAAR1 and D2R heteromers.
The different functionality of rat Taar subtypes 1 and 4 mainly correlates with receptor's cell surface expression rather than with specific amino acid residues involved in ligand binding specificity.
Title: Determinants involved in subtype-specific functions of rat trace amine-associated receptors 1 and 4.
Data show that TAARs were expressed only at trace amounts in most of the tissues, the exceptions being TAAR1 in stomach and testis and TAAR8a in intestine, spleen, and testis.
Title: Distribution of exogenous [125I]-3-iodothyronamine in mouse in vivo: relationship with trace amine-associated receptors.
Overview focuses on recent studies which reveal a role for TAAR1 in the functional regulation of monoamine transporters and the neuronal regulatory mechanisms that modulate dopaminergic activity. [review]
Title: The emerging role of trace amine-associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activity.
The Tyramine highly concentrated in the median eminence of the mediobasal hypothalamus, in which its physiological function on prolactin release has been demonstrated.
Title: Tyramine-immunoreactive neuronal structures in the rat brain: abundance in the median eminence of the mediobasal hypothalamus.

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General gene information

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Markers

Taar1 (e-PCR), detects polymorphism
- UniSTS:516726

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled amine receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables trace-amine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables trace-amine receptor activity	IEA Inferred from Electronic Annotation more info
enables trace-amine receptor activity	ISO Inferred from Sequence Orthology more info
enables trace-amine receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cAMP/PKA signal transduction	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in endomembrane system	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: trace amine-associated receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134328.1 → NP_599155.1 trace amine-associated receptor 1

See identical proteins and their annotated locations for NP_599155.1

Status: PROVISIONAL

Source sequence(s)

AF421352

UniProtKB/Swiss-Prot

Q5QD26, Q8VHQ5, Q923Y9

UniProtKB/TrEMBL

A0A0G2JSP2, A6JUN2

Related

ENSRNOP00000021510.1, ENSRNOT00000021510.4

Conserved Domains (2) summary

pfam00001
Location:39 → 301

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:30 → 164

7tm_4; Olfactory receptor