Crcp CGRP receptor component [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Crcpprovided by RGD
Official Full Name: CGRP receptor componentprovided by RGD
Primary source: RGD:620753
See related: EnsemblRapid:ENSRNOG00000071267 AllianceGenome:RGD:620753
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cgrp-rcp
Summary: Predicted to enable DNA-directed 5'-3' RNA polymerase activity and calcitonin gene-related peptide receptor activity. Predicted to be involved in transcription initiation at RNA polymerase III promoter. Predicted to act upstream of or within neuropeptide signaling pathway. Located in axon; dendrite; and neuronal cell body. Biomarker of sciatic neuropathy. Orthologous to human CRCP (CGRP receptor component). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 115.6), Spleen (RPKM 102.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q12

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (32260108..32315116, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (26623968..26659756, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (30125237..30160857, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The alleviating effect of non-excitatory electrical stimulation in myocardial infarction may be associated with modulation of endogenous CGRP expression in the myocardium.
Title: Non-excitatory electrical stimulation attenuates myocardial infarction via homeostasis of calcitonin gene-related peptide in myocardium.
CGRP receptor is widely distributed in the trigeminovascular system and other pain- processing brain structures.
Title: mRNA distribution of CGRP and its receptor components in the trigeminovascular system and other pain related structures in rat brain, and effect of intracerebroventricular administration of CGRP on Fos expression in the TNC.
These data suggest that CGRP is expressed in C-fibers and may act on A-fibers, rodent mast cells, and vascular smooth muscle cells that express the CGRP receptor.
Title: Differentiation of nerve fibers storing CGRP and CGRP receptors in the peripheral trigeminovascular system.
This study demonstrates the detailed expression of CGRP and its receptor components within spinal trigeminal nucleus in the brainstem and in the spinal cord at C1-level
Title: Calcitonin gene-related peptide (CGRP) and its receptor components in human and rat spinal trigeminal nucleus and spinal cord at C1-level.
Functional CGRP receptors are detected in trigeminal satellite cells, a specialized type of glia found within the sensory ganglia.
Title: Trigeminal satellite cells express functional calcitonin gene-related peptide receptors, whose activation enhances interleukin-1β pro-inflammatory effects.
We aimed to investigate mechanisms that mediate CGRP release from the rat colon in vitro
Title: Characterization of a calcitonin gene-related peptide release assay in rat isolated distal colon.
Intrinsic cardiac adrenergic cells constitute a delta-opioid-regulated adrenopeptidergic paracrine system conferring robust cardioprotection through beta(2)-AR/CGRP-R co-signalling.
Title: Reducing ischaemia/reperfusion injury through delta-opioid-regulated intrinsic cardiac adrenergic cells: adrenopeptidergic co-signalling.
Data suggest that prolonged increase in NO levels facilitates stimulated CGRP release from trigeminal ganglion neurons, and that delayed headaches induced by NO may change CGRP or CGRP-receptor expression.
Title: Glyceroltrinitrate facilitates stimulated CGRP release but not gene expression of CGRP or its receptor components in rat trigeminal ganglia.
evidence for increased coupling of CGRP receptors to adenylyl cyclase in early pregnancy
Title: Mechanisms leading to increased vasodilator responses to calcitonin-gene-related peptide in mesenteric resistance arteries of early pregnant rats.
Neurokinin 1 receptor activation, induced by Substance P release upon TRPV1 activation, governs TRPV1 function; a TRPV1-dependent mechanism is operant in calcitonin gene-related peptide action.
Title: Interdependent regulation of afferent renal nerve activity and renal function: role of transient receptor potential vanilloid type 1, neurokinin 1, and calcitonin gene-related peptide receptors.

Submit: New GeneRIF Correction See all GeneRIFs (17)

General gene information

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Markers

RH135206 (e-PCR)
- UniSTS:218483

D12Rat83 (e-PCR), detects polymorphism
- UniSTS:226477

BF388305 (e-PCR)
- UniSTS:244919

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-directed 5'-3' RNA polymerase activity	ISO Inferred from Sequence Orthology more info
enables DNA-directed 5'-3' RNA polymerase activity	ISS Inferred from Sequence or Structural Similarity more info
enables calcitonin gene-related peptide receptor activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables quinone binding	IEA Inferred from Electronic Annotation more info
enables vitamin-K-epoxide reductase (warfarin-sensitive) activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in transcription by RNA polymerase III	ISO Inferred from Sequence Orthology more info
involved_in transcription by RNA polymerase III	ISS Inferred from Sequence or Structural Similarity more info
involved_in transcription initiation at RNA polymerase III promoter	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription initiation at RNA polymerase III promoter	IEA Inferred from Electronic Annotation more info
involved_in vitamin K metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of DNA polymerase III complex	ISO Inferred from Sequence Orthology more info
part_of DNA polymerase III complex	ISS Inferred from Sequence or Structural Similarity more info
part_of RNA polymerase III complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase III complex	IEA Inferred from Electronic Annotation more info
part_of RNA polymerase III complex	ISO Inferred from Sequence Orthology more info
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA-directed RNA polymerase III subunit RPC9

Names: CGRP-receptor component protein; CGRPRCP; RNA polymerase III subunit C9; calcitonin gene-related peptide-receptor component protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053670.3 → NP_446122.1 DNA-directed RNA polymerase III subunit RPC9

See identical proteins and their annotated locations for NP_446122.1

Status: PROVISIONAL

Source sequence(s)

AF440799

UniProtKB/Swiss-Prot

Q8VHM6, Q9Z0W9

UniProtKB/TrEMBL

A0A8I5XVS4, A6J0N3

Related

ENSRNOP00000098382.1, ENSRNOT00000120757.2

Conserved Domains (1) summary

smart00657
Location:1 → 126

RPOL4c; DNA-directed RNA-polymerase II subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

32260108..32315116 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063270985.1 → XP_063127055.1 DNA-directed RNA polymerase III subunit RPC9 isoform X1

UniProtKB/TrEMBL

A0A8I5XVS4, F8WFG9

Related

ENSRNOP00000101135.1, ENSRNOT00000136822.1
XM_039089011.1 → XP_038944939.1 DNA-directed RNA polymerase III subunit RPC9 isoform X2

Conserved Domains (1) summary

cl00638
Location:1 → 54

RNA_pol_Rpb4; RNA polymerase Rpb4