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    Apol9a apolipoprotein L9a [ Rattus norvegicus (Norway rat) ]

    Gene ID: 503164, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Apol9aprovided by RGD
    Official Full Name
    apolipoprotein L9aprovided by RGD
    Primary source
    RGD:1562332
    See related
    EnsemblRapid:ENSRNOG00000023410 AllianceGenome:RGD:1562332
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable lipid binding activity. Predicted to be involved in lipid transport and lipoprotein metabolic process. Predicted to be located in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human APOL1 (apolipoprotein L1) and APOL2 (apolipoprotein L2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 223.4), Liver (RPKM 106.0) and 7 other tissues See more
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    Genomic context

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    See Apol9a in Genome Data Viewer
    Location:
    7q34
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (111021452..111030380, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (109140871..109149799, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (118927013..118933778, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093818 Neighboring gene Apol9a-Apol7a readthrough Neighboring gene apolipoprotein L7b, pseudogene 1 Neighboring gene apolipoprotein L3-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Readthrough Apol9a-Apol7a

    Readthrough gene: Apol9a-Apol7a, Included gene: Apol7a

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables lipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipoprotein metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    apolipoprotein L 9a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025066.2 → NP_001020237.1  apolipoprotein L 9a isoform 1

      See identical proteins and their annotated locations for NP_001020237.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      Q5XIB6
      Related
      ENSRNOP00000036679.3, ENSRNOT00000031951.6
      Conserved Domains (1) summary
      pfam05461
      Location:1 → 313
      ApoL; Apolipoprotein L

    2. NM_001429364.1 → NP_001416293.1  apolipoprotein L 9a isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      Q5XIB6

    3. NM_001429365.1 → NP_001416294.1  apolipoprotein L 9a isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      Q5XIB6

    4. NM_001429366.1 → NP_001416295.1  apolipoprotein L 9a isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      Q5XIB6

    5. NM_001429367.1 → NP_001416296.1  apolipoprotein L 9a isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007

    6. NM_001429368.1 → NP_001416297.1  apolipoprotein L 9a isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007

    7. NM_001429369.1 → NP_001416298.1  apolipoprotein L 9a isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007

    8. NM_001429370.1 → NP_001416299.1  apolipoprotein L 9a isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007

    9. NM_001429377.1 → NP_001416306.1  apolipoprotein L 9a isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      Q5XIB6

    10. NM_001429378.1 → NP_001416307.1  apolipoprotein L 9a isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      Q5XIB6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      111021452..111030380 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079781.1 → XP_038935709.1  apolipoprotein L 9a isoform X1

      Conserved Domains (1) summary
      pfam05461
      Location:1 → 313
      ApoL; Apolipoprotein L

    2. XM_008765642.4 → XP_008763864.1  apolipoprotein L 9a isoform X2

      Conserved Domains (1) summary
      pfam05461
      Location:38 → 323
      ApoL; Apolipoprotein L

    3. XM_063264153.1 → XP_063120223.1  apolipoprotein L 9a isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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