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    Map3k6 mitogen-activated protein kinase kinase kinase 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313022, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Map3k6provided by RGD
    Official Full Name
    mitogen-activated protein kinase kinase kinase 6provided by RGD
    Primary source
    RGD:1304625
    See related
    EnsemblRapid:ENSRNOG00000008936 AllianceGenome:RGD:1304625
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP binding activity; MAP kinase kinase kinase activity; and magnesium ion binding activity. Predicted to be involved in JNK cascade; p38MAPK cascade; and protein phosphorylation. Orthologous to human MAP3K6 (mitogen-activated protein kinase kinase kinase 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 29.3), Adrenal (RPKM 16.0) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Map3k6 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (150724029..150736113)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (145440126..145452213)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (151435679..151448329)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 3 Neighboring gene CD164 molecule like 2 Neighboring gene synaptotagmin-like 1 Neighboring gene transmembrane protein 222 Neighboring gene uncharacterized LOC134487005

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MAPKKK6, a novel mitogen-activated protein kinase kinase kinase, that associates with MAPKKK5. Wang XS, et al. Biochem Biophys Res Commun, 1998 Dec 9. PMID 9875215
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables JUN kinase kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP kinase kinase kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in p38MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase kinase kinase 6
    NP_001101379.1
    XP_006239081.1
    XP_006239082.1
    XP_006239084.1
    XP_008762359.1
    XP_038965707.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107909.1 → NP_001101379.1  mitogen-activated protein kinase kinase kinase 6

      See identical proteins and their annotated locations for NP_001101379.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473968
      UniProtKB/TrEMBL
      A6ISW1, D3ZFL3
      Related
      ENSRNOP00000012463.5, ENSRNOT00000012463.7
      Conserved Domains (3) summary
      smart00220
      Location:654 → 907
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06624
      Location:640 → 907
      STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
      pfam13281
      Location:130 → 507
      DUF4071; Domain of unknown function (DUF4071)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      150724029..150736113
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006239020.5 → XP_006239082.1  mitogen-activated protein kinase kinase kinase 6 isoform X2

      Conserved Domains (3) summary
      smart00220
      Location:646 → 899
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06624
      Location:632 → 899
      STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
      pfam13281
      Location:130 → 499
      DUF4071; Domain of unknown function (DUF4071)

    2. XM_006239019.5 → XP_006239081.1  mitogen-activated protein kinase kinase kinase 6 isoform X1

      Conserved Domains (3) summary
      smart00220
      Location:654 → 907
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06624
      Location:640 → 907
      STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
      pfam13281
      Location:130 → 507
      DUF4071; Domain of unknown function (DUF4071)

    3. XM_008764137.4 → XP_008762359.1  mitogen-activated protein kinase kinase kinase 6 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZR53
      Related
      ENSRNOP00000080621.1, ENSRNOT00000093926.2
      Conserved Domains (3) summary
      smart00220
      Location:646 → 899
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06624
      Location:632 → 899
      STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
      pfam13281
      Location:130 → 499
      DUF4071; Domain of unknown function (DUF4071)

    4. XM_039109779.2 → XP_038965707.1  mitogen-activated protein kinase kinase kinase 6 isoform X4

      Conserved Domains (3) summary
      cd06624
      Location:432 → 699
      STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
      pfam13281
      Location:24 → 300
      DUF4071; Domain of unknown function (DUF4071)
      pfam19039
      Location:316 → 406
      ASK_PH; ASK kinase PH domain

    5. XM_006239022.5 → XP_006239084.1  mitogen-activated protein kinase kinase kinase 6 isoform X4

      Conserved Domains (3) summary
      cd06624
      Location:432 → 699
      STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
      pfam13281
      Location:24 → 300
      DUF4071; Domain of unknown function (DUF4071)
      pfam19039
      Location:316 → 406
      ASK_PH; ASK kinase PH domain
    Nucleotide Protein Strain
    Heading Accession and Version

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