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    Ahcyl2 adenosylhomocysteinase-like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312192, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ahcyl2provided by RGD
    Official Full Name
    adenosylhomocysteinase-like 2provided by RGD
    Primary source
    RGD:1564895
    See related
    EnsemblRapid:ENSRNOG00000039300 AllianceGenome:RGD:1564895
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564895
    Summary
    Predicted to be involved in S-adenosylmethionine cycle. Predicted to be located in intracellular membrane-bounded organelle and neuron projection. Predicted to be active in cytosol. Orthologous to human AHCYL2 (adenosylhomocysteinase like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 334.7), Adrenal (RPKM 280.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ahcyl2 in Genome Data Viewer
    Location:
    4q22
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (59348747..59498503)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (58381290..58531061)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (57050241..57199870)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene smoothened, frizzled class receptor Neighboring gene uncharacterized LOC120102483 Neighboring gene large ribosomal subunit protein eL19-like Neighboring gene striatin interacting protein 2 Neighboring gene phosphoglycerate kinase 1, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. An IRBIT homologue lacks binding activity to inositol 1,4,5-trisphosphate receptor due to the unique N-terminal appendage. Ando H, et al. J Neurochem, 2009 Apr. PMID 19220705
    2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables adenosylhomocysteinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in S-adenosylmethionine cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in one-carbon metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    adenosylhomocysteinase 3
    Names
    S-adenosylhomocysteine hydrolase-like 2
    putative adenosylhomocysteinase 3
    NP_001166981.2
    XP_006236256.1
    XP_008760993.1
    XP_063142050.1
    XP_063142051.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001173510.2 → NP_001166981.2  adenosylhomocysteinase 3

      See identical proteins and their annotated locations for NP_001166981.2

      Status: VALIDATED

      Source sequence(s)
      BQ781566, CB713115, CV113234, FM059920, FN804654, JAXUCZ010000004
      UniProtKB/TrEMBL
      A6IEE7, D3ZWL6
      Related
      ENSRNOP00000091272.2, ENSRNOT00000100143.2
      Conserved Domains (2) summary
      PRK05476
      Location:186 → 606
      PRK05476; S-adenosyl-L-homocysteine hydrolase; Provisional
      pfam05221
      Location:186 → 611
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      59348747..59498503
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008762771.4 → XP_008760993.1  adenosylhomocysteinase 3 isoform X1

      See identical proteins and their annotated locations for XP_008760993.1

      UniProtKB/TrEMBL
      A0A8I6A7Z2, A0A8I6ABA9
      Conserved Domains (1) summary
      smart00996
      Location:84 → 507
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase

    2. XM_063285981.1 → XP_063142051.1  adenosylhomocysteinase 3 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZKU2
      Related
      ENSRNOP00000078402.1, ENSRNOT00000102598.2

    3. XM_063285980.1 → XP_063142050.1  adenosylhomocysteinase 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A7Z2, A0A8I6ABA9
      Related
      ENSRNOP00000108445.1, ENSRNOT00000133936.1

    4. XM_006236194.5 → XP_006236256.1  adenosylhomocysteinase 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A7Z2
      Related
      ENSRNOP00000087181.2, ENSRNOT00000109374.2
      Conserved Domains (2) summary
      PRK05476
      Location:82 → 502
      PRK05476; S-adenosyl-L-homocysteine hydrolase; Provisional
      pfam05221
      Location:82 → 507
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase
    Nucleotide Protein Strain
    Heading Accession and Version

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