Ppm1n protein phosphatase, Mg2+/Mn2+ dependent 1N [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ppm1nprovided by RGD
Official Full Name: protein phosphatase, Mg2+/Mn2+ dependent 1Nprovided by RGD
Primary source: RGD:1562091
See related: EnsemblRapid:ENSRNOG00000058133 AllianceGenome:RGD:1562091
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1562091
Summary: Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway and regulation of canonical NF-kappaB signal transduction. Predicted to be active in cytosol and nucleus. Orthologous to human PPM1N (protein phosphatase, Mg2+/Mn2+ dependent 1N (putative)). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 34.7), Lung (RPKM 11.4) and 8 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 1q21

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (88057365..88062912, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (78929350..78934435, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (80190293..80193002, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1 Unlocalized Scaffold	NW_007906109.1 (30397..32840, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables MAP kinase serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables calmodulin-dependent protein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS140 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables manganese ion binding	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: probable protein phosphatase 1N

NP_001099701.2

EC 3.1.3.16

XP_038959919.1

EC 3.1.3.16

XP_038959920.1

EC 3.1.3.16

XP_038959930.1

EC 3.1.3.16

XP_038959941.1

EC 3.1.3.16

XP_038959952.1

EC 3.1.3.16

XP_038959963.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106231.2 → NP_001099701.2 probable protein phosphatase 1N

See identical proteins and their annotated locations for NP_001099701.2

Status: PROVISIONAL

Source sequence(s)

CH473979

UniProtKB/TrEMBL

A6J8L9, D3ZP99

Conserved Domains (2) summary

cd00143
Location:59 → 319

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

pfam07830
Location:313 → 387

PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

88057365..88062912 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039104035.2 → XP_038959963.1 probable protein phosphatase 1N isoform X4

Conserved Domains (2) summary

cd00143
Location:59 → 319

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

cl29762
Location:313 → 345

PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
XM_039104024.2 → XP_038959952.1 probable protein phosphatase 1N isoform X4

Conserved Domains (2) summary

cd00143
Location:59 → 319

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

cl29762
Location:313 → 345

PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
XM_039104013.2 → XP_038959941.1 probable protein phosphatase 1N isoform X3

Conserved Domains (2) summary

cd00143
Location:59 → 319

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

cl29762
Location:313 → 345

PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
XM_039104002.2 → XP_038959930.1 probable protein phosphatase 1N isoform X2

Conserved Domains (2) summary

cd00143
Location:59 → 319

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

pfam07830
Location:313 → 390

PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
XM_039103992.2 → XP_038959920.1 probable protein phosphatase 1N isoform X1

Related

ENSRNOP00000069023.3, ENSRNOT00000089197.3

Conserved Domains (2) summary

cd00143
Location:59 → 319

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

cl29762
Location:313 → 345

PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
XM_039103991.2 → XP_038959919.1 probable protein phosphatase 1N isoform X1

Conserved Domains (2) summary

cd00143
Location:59 → 319

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

cl29762
Location:313 → 345

PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain