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    Pradc1 protease-associated domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 686393, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pradc1provided by RGD
    Official Full Name
    protease-associated domain containing 1provided by RGD
    Primary source
    RGD:1583112
    See related
    EnsemblRapid:ENSRNOG00000050483 AllianceGenome:RGD:1583112
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be located in extracellular region. Orthologous to human PRADC1 (protease associated domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 77.0), Kidney (RPKM 72.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pradc1 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (119542239..119546536, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (117984732..117989710, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (117230523..117235496, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene notochord homeobox Neighboring gene SMYD family member 5 Neighboring gene chaperonin containing TCP1 subunit 7 Neighboring gene F-box protein 41

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. N-glycosylation is required for efficient secretion of a novel human secreted glycoprotein, hPAP21. Zhou YB, et al. FEBS Lett, 2004 Oct 22. PMID 15498570
    2. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protease-associated domain containing 1; protease-associated domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431907.1 → NP_001418836.1  protease-associated domain containing 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6A5A4, A6IAR8, M0R5K7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      119542239..119546536 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236797.5 → XP_006236859.1  protease-associated domain-containing protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006236859.1

      UniProtKB/TrEMBL
      A0A8I6AQD2
      Related
      ENSRNOP00000096090.1, ENSRNOT00000101311.2
      Conserved Domains (1) summary
      cl28883
      Location:51 → 112
      PA; Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain. At ...

    2. XM_003749786.6 → XP_003749834.1  protease-associated domain-containing protein 1 isoform X1

      Related
      ENSRNOP00000064676.1, ENSRNOT00000073135.5
      Conserved Domains (1) summary
      cd02127
      Location:51 → 168
      PA_hPAP21_like; Protease-associated domain containing proteins like the human secreted glycoprotein hPAP21 (human protease-associated domain-containing protein, 21kDa). This group contains various PA domain-containing proteins similar to hPAP21. Complex N-glycosylation ...
    Nucleotide Protein Strain
    Heading Accession and Version

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