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    Ggt5 gamma-glutamyltransferase 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29566, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ggt5provided by RGD
    Official Full Name
    gamma-glutamyltransferase 5provided by RGD
    Primary source
    RGD:2684
    See related
    EnsemblRapid:ENSRNOG00000062276 AllianceGenome:RGD:2684
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ggta1; Ggtla1
    Summary
    Predicted to enable glutathione hydrolase activity; leukotriene-C(4) hydrolase; and peptidyltransferase activity. Predicted to be involved in several processes, including carboxylic acid metabolic process; glutathione catabolic process; and inflammatory response. Predicted to be active in plasma membrane. Orthologous to human GGT5 (gamma-glutamyltransferase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 21.6), Heart (RPKM 16.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ggt5 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (13042694..13070960, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (13043255..13071523, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (13988444..14001296, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene calcineurin binding protein 1 Neighboring gene uncharacterized LOC102556116 Neighboring gene sushi domain containing 2 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120098976 Neighboring gene gamma-glutamyltransferase 1 Neighboring gene leucine rich repeat containing 75B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. gamma-glutamyl leukotrienase, a gamma-glutamyl transpeptidase gene family member, is expressed primarily in spleen. Carter BZ, et al. J Biol Chem, 1998 Oct 23. PMID 9774450
    2. Expression and regulation of gamma-glutamyl transpeptidase-related enzyme in tracheal cells. Potdar PD, et al. Am J Physiol, 1997 Nov. PMID 9374738
    3. Identification of a human gamma-glutamyl cleaving enzyme related to, but distinct from, gamma-glutamyl transpeptidase. Heisterkamp N, et al. Proc Natl Acad Sci U S A, 1991 Jul 15. PMID 1676842, Free PMC Article
    4. Gamma-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D(4) formation in vivo. Han B, et al. Am J Pathol, 2002 Aug. PMID 12163373, Free PMC Article
    5. Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl transpeptidase enzymes. Wickham S, et al. Anal Biochem, 2011 Jul 15. PMID 21447318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC93485

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables glutathione hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables leukotriene C4 gamma-glutamyl transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables leukotriene-C(4) hydrolase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables leukotriene-C(4) hydrolase IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables leukotriene-C(4) hydrolase ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables leukotriene-C(4) hydrolase ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables peptidyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glutathione biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutathione catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutathione catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glutathione catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leukotriene D4 biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leukotriene D4 biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within leukotriene D4 biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leukotriene D4 biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leukotriene D4 biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to oxidative stress TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    glutathione hydrolase 5 proenzyme
    Names
    GGL
    GGT 5
    GGT-rel
    gamma-glutamyl leukotrienase
    gamma-glutamyl transpeptidase-related enzyme
    gamma-glutamyltransferase-like activity 1
    gamma-glutamyltranspeptidase 5
    leukotriene-C4 hydrolase
    NP_062108.2
    XP_038954554.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019235.2 → NP_062108.2  glutathione hydrolase 5 proenzyme

      See identical proteins and their annotated locations for NP_062108.2

      Status: PROVISIONAL

      Source sequence(s)
      BC087018
      UniProtKB/Swiss-Prot
      Q5PQV0, Q9QWE9
      Related
      ENSRNOP00000076334.2, ENSRNOT00000093720.3
      Conserved Domains (1) summary
      pfam01019
      Location:60 → 567
      G_glu_transpept; Gamma-glutamyltranspeptidase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      13042694..13070960 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098626.2 → XP_038954554.1  glutathione hydrolase 5 proenzyme isoform X1

      Conserved Domains (1) summary
      pfam01019
      Location:60 → 524
      G_glu_transpept; Gamma-glutamyltranspeptidase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QWE9.2 GenPept UniProtKB/Swiss-Prot:Q9QWE9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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