Clcnkb chloride voltage-gated channel Kb [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Clcnkbprovided by RGD
Official Full Name: chloride voltage-gated channel Kbprovided by RGD
Primary source: RGD:628639
See related: EnsemblRapid:ENSRNOG00000009897 AllianceGenome:RGD:628639
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Clck2; ClC-K2L; Clcnk1l
Summary: This gene is a member of the CLC family of voltage-gated chloride channels. The gene is located adjacent to a highly similar chloride channel gene on chromosome 5. This gene is syntenic with human CLCNKA (geneID:1187).[provided by RefSeq, Sep 2009]
Expression: Biased expression in Kidney (RPKM 404.0) and Heart (RPKM 28.1) See more
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Genomic context

Location:: 5q36

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (158993073..159005618, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (153710086..153733162, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (159950384..159973576, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The present study showed that adenosine affected the mRNA expression of CLCNKB, initially through the cAMPPKA pathway and then the PLA2AA pathway.
Title: Effects of adenosine stimulation on the mRNA expression of CLCNKB in the basolateral medullary thick ascending limb of the rat kidney.
In salt-sensitive hypertension, there is a strong upregulation, both of NCC and ClC-K along the distal convoluted tubules, which explains the persistence of hypertension.
Title: Upregulation of apical sodium-chloride cotransporter and basolateral chloride channels is responsible for the maintenance of salt-sensitive hypertension.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chloride channel activity	IDA Inferred from Direct Assay more info	PubMed
enables chloride channel activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables voltage-gated chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated chloride channel activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated chloride channel activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in chloride transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of intracellular pH	IEA Inferred from Electronic Annotation more info
involved_in regulation of intracellular pH	ISO Inferred from Sequence Orthology more info
involved_in renal absorption	IEA Inferred from Electronic Annotation more info
involved_in renal absorption	ISO Inferred from Sequence Orthology more info
involved_in renal absorption	TAS Traceable Author Statement more info	PubMed
involved_in renal sodium ion absorption	ISO Inferred from Sequence Orthology more info
involved_in transepithelial chloride transport	IEA Inferred from Electronic Annotation more info
involved_in transepithelial chloride transport	ISO Inferred from Sequence Orthology more info
involved_in transepithelial chloride transport	NAS Non-traceable Author Statement more info	PubMed
involved_in transepithelial chloride transport	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: chloride channel protein ClC-Kb

Names: chloride channel K2; chloride channel Kb; chloride channel, voltage-sensitive Kb; clC-K2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173103.1 → NP_775126.1 chloride channel protein ClC-Kb

See identical proteins and their annotated locations for NP_775126.1

Status: PROVISIONAL

Source sequence(s)

Z30663

UniProtKB/Swiss-Prot

P51802

UniProtKB/TrEMBL

A6ITT3

Related

ENSRNOP00000082436.2, ENSRNOT00000101714.2

Conserved Domains (3) summary

cd03683
Location:49 → 533

ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...

pfam00571
Location:547 → 604

CBS; CBS domain

pfam00654
Location:106 → 513

Voltage_CLC; Voltage gated chloride channel

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

158993073..159005618 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063288467.1 → XP_063144537.1 chloride channel protein ClC-Kb isoform X1

UniProtKB/TrEMBL

A6ITT2, A6ITT3
XM_063288469.1 → XP_063144539.1 chloride channel protein ClC-Kb isoform X4

UniProtKB/TrEMBL

Q1W581
XM_008764297.4 → XP_008762519.1 chloride channel protein ClC-Kb isoform X3

UniProtKB/TrEMBL

E9PTA8, Q1W581

Related

ENSRNOP00000049598.4, ENSRNOT00000050729.6

Conserved Domains (2) summary

cd03683
Location:49 → 490

ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...

cd04591
Location:503 → 633

CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria
XM_063288468.1 → XP_063144538.1 chloride channel protein ClC-Kb isoform X2

UniProtKB/TrEMBL

A0A8I5ZU48, A6ITT3