Cpa4 carboxypeptidase A4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cpa4provided by RGD
Official Full Name: carboxypeptidase A4provided by RGD
Primary source: RGD:1563619
See related: EnsemblRapid:ENSRNOG00000010463 AllianceGenome:RGD:1563619
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1563619
Summary: Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in hormone catabolic process; peptide catabolic process; and proteolysis. Predicted to be active in extracellular space. Orthologous to human CPA4 (carboxypeptidase A4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 13.7), Testes (RPKM 6.5) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q22

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (60155675..60179644)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (59188284..59212255)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (57883849..57907826)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Carboxypeptidase A4 promotes cardiomyocyte hypertrophy through activating PI3K-AKT-mTOR signaling.
Title: Carboxypeptidase A4 promotes cardiomyocyte hypertrophy through activating PI3K-AKT-mTOR signaling.

Submit: New GeneRIF Correction

General gene information

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Markers

Cpa4 (e-PCR), detects polymorphism
- UniSTS:527293

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metallocarboxypeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallocarboxypeptidase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in hormone catabolic process	ISO Inferred from Sequence Orthology more info
involved_in peptide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: carboxypeptidase A4

NP_001102816.1

EC 3.4.17.15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109346.2 → NP_001102816.1 carboxypeptidase A4 precursor

See identical proteins and their annotated locations for NP_001102816.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A6IEG9, D3ZHS5

Related

ENSRNOP00000013880.3, ENSRNOT00000013880.7

Conserved Domains (2) summary

cd03870
Location:117 → 419

M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup

pfam02244
Location:32 → 101

Propep_M14; Carboxypeptidase activation peptide