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    Fiz1 FLT3-interacting zinc finger 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292584, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fiz1provided by RGD
    Official Full Name
    FLT3-interacting zinc finger 1provided by RGD
    Primary source
    RGD:1306359
    See related
    EnsemblRapid:ENSRNOG00000016574 AllianceGenome:RGD:1306359
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306359
    Summary
    Predicted to enable receptor tyrosine kinase binding activity. Predicted to act upstream of or within positive regulation of protein phosphorylation. Predicted to be located in chromatin; cytoplasm; and nucleus. Orthologous to human FIZ1 (FLT3 interacting zinc finger 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 51.3), Heart (RPKM 46.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fiz1 in Genome Data Viewer
    Location:
    1q12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (77856901..77864562)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (68822741..68835723)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (72379705..72387301)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 865 Neighboring gene zinc finger protein 524 Neighboring gene zinc finger protein 579 Neighboring gene SH3 domain binding kinase family, member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Fiz1, a novel zinc finger protein interacting with the receptor tyrosine kinase Flt3. Wolf I, et al. J Biol Chem, 1999 Jul 23. PMID 10409713
    2. Dual retrovirus integration tagging: identification of new signaling molecules Fiz1 and Hipk2 that are involved in the IL-7 signaling pathway in B lymphoblastic lymphomas. Tsuruyama T, et al. J Leukoc Biol, 2010 Jul. PMID 20360400

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    flt3-interacting zinc finger protein 1
    Names
    Flt3 interacting zinc finger protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106223.1 → NP_001099693.1  flt3-interacting zinc finger protein 1

      See identical proteins and their annotated locations for NP_001099693.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474075
      UniProtKB/TrEMBL
      A0A8I5ZTJ4, A6KNR1, D3ZP93
      Conserved Domains (4) summary
      sd00017
      Location:417 → 437
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:203 → 223
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:471 → 493
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:429 → 454
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      77856901..77864562
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103834.2 → XP_038959762.1  flt3-interacting zinc finger protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZTJ4, A6KNR1, D3ZP93
      Conserved Domains (4) summary
      sd00017
      Location:417 → 437
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:203 → 223
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:471 → 493
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:429 → 454
      zf-H2C2_2; Zinc-finger double domain

    2. XM_017588890.3 → XP_017444379.1  flt3-interacting zinc finger protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZTJ4, A6KNR1, D3ZP93
      Conserved Domains (4) summary
      sd00017
      Location:417 → 437
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:203 → 223
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:471 → 493
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:429 → 454
      zf-H2C2_2; Zinc-finger double domain

    3. XM_006228252.4 → XP_006228314.1  flt3-interacting zinc finger protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006228314.1

      UniProtKB/TrEMBL
      A0A8I5ZTJ4, A6KNR1, D3ZP93
      Conserved Domains (4) summary
      sd00017
      Location:417 → 437
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:203 → 223
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:471 → 493
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:429 → 454
      zf-H2C2_2; Zinc-finger double domain

    4. XM_006228253.5 → XP_006228315.1  flt3-interacting zinc finger protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006228315.1

      UniProtKB/TrEMBL
      A0A8I5ZTJ4, A6KNR1, D3ZP93
      Conserved Domains (4) summary
      sd00017
      Location:417 → 437
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:203 → 223
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:471 → 493
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:429 → 454
      zf-H2C2_2; Zinc-finger double domain

    5. XM_006228254.5 → XP_006228316.1  flt3-interacting zinc finger protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006228316.1

      UniProtKB/TrEMBL
      A0A8I5ZTJ4, A6KNR1, D3ZP93
      Related
      ENSRNOP00000101970.1, ENSRNOT00000153889.1
      Conserved Domains (4) summary
      sd00017
      Location:417 → 437
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:203 → 223
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:471 → 493
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:429 → 454
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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