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    Pou2af1 POU class 2 homeobox associating factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 690528, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pou2af1provided by RGD
    Official Full Name
    POU class 2 homeobox associating factor 1provided by RGD
    Primary source
    RGD:1594728
    See related
    EnsemblRapid:ENSRNOG00000011500 AllianceGenome:RGD:1594728
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA binding activity and transcription coactivator activity. Predicted to be involved in cellular response to virus; germinal center B cell differentiation; and positive regulation of macromolecule biosynthetic process. Predicted to be part of RNA polymerase II transcription regulator complex. Orthologous to human POU2AF1 (POU class 2 homeobox associating factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 219.4), Thymus (RPKM 53.4) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Pou2af1 in Genome Data Viewer
    Location:
    8q23
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (60418173..60445176)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (51521813..51548819)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (55603968..55631448)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480166 Neighboring gene BTG anti-proliferation factor 4 Neighboring gene RGD1562811 Neighboring gene uncharacterized LOC103693092 Neighboring gene POU class 2 homeobox associating factor 3 Neighboring gene POU class 2 homeobox associating factor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding  
    enables POU domain binding  
    enables transcription coactivator activity  
    enables transcription coactivator activity  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex  
    part_of RNA polymerase II transcription regulator complex  

    General protein information

    Preferred Names
    POU domain class 2-associating factor 1
    Names
    POU class 2 associating factor 1
    POU domain, class 2, associating factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109599.1NP_001103069.1  POU domain class 2-associating factor 1

      See identical proteins and their annotated locations for NP_001103069.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473975
      UniProtKB/TrEMBL
      A0A8I6A679, A6J4H1, D4A397
      Related
      ENSRNOP00000061720.2, ENSRNOT00000066848.3
      Conserved Domains (1) summary
      pfam09310
      Location:7255
      PD-C2-AF1; POU domain, class 2, associating factor 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      60418173..60445176
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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