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    Mthfsd methenyltetrahydrofolate synthetase domain containing [ Rattus norvegicus (Norway rat) ]

    Gene ID: 687539, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mthfsdprovided by RGD
    Official Full Name
    methenyltetrahydrofolate synthetase domain containingprovided by RGD
    Primary source
    RGD:1584226
    See related
    EnsemblRapid:ENSRNOG00000046443 AllianceGenome:RGD:1584226
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA binding activity. Orthologous to human MTHFSD (methenyltetrahydrofolate synthetase domain containing). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 30.2), Thymus (RPKM 30.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mthfsd in Genome Data Viewer
    Location:
    19q12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (66072952..66086917, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (49164266..49178233, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (53025526..53036559, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene FOXF1 adjacent non-coding developmental regulatory RNA Neighboring gene forkhead box F1 Neighboring gene forkhead box C2 Neighboring gene forkhead box L1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    methenyltetrahydrofolate synthase domain-containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401041.1 → NP_001387970.1  methenyltetrahydrofolate synthase domain-containing protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A8I5ZVM1
      Related
      ENSRNOP00000108744.1, ENSRNOT00000137936.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      66072952..66086917 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098339.2 → XP_038954267.1  methenyltetrahydrofolate synthase domain-containing protein isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZVM1, M0R5E8
      Related
      ENSRNOP00000112367.1, ENSRNOT00000157780.1
      Conserved Domains (2) summary
      cl00360
      Location:32 → 229
      5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family
      cl17169
      Location:339 → 408
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. XM_063278279.1 → XP_063134349.1  methenyltetrahydrofolate synthase domain-containing protein isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZVM1

    3. XM_063278280.1 → XP_063134350.1  methenyltetrahydrofolate synthase domain-containing protein isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZVM1

    4. XM_063278281.1 → XP_063134351.1  methenyltetrahydrofolate synthase domain-containing protein isoform X4

    5. XM_063278282.1 → XP_063134352.1  methenyltetrahydrofolate synthase domain-containing protein isoform X4

    6. XM_039098340.1 → XP_038954268.1  methenyltetrahydrofolate synthase domain-containing protein isoform X5

      Conserved Domains (1) summary
      cl00360
      Location:32 → 167
      5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family
    Nucleotide Protein Strain
    Heading Accession and Version

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