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    Sult4a1 sulfotransferase family 4A, member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 58953, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sult4a1provided by RGD
    Official Full Name
    sulfotransferase family 4A, member 1provided by RGD
    Primary source
    RGD:69292
    See related
    EnsemblRapid:ENSRNOG00000046975 AllianceGenome:RGD:69292
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ST4A1; Sultx3; Sulta41
    Summary
    Predicted to enable identical protein binding activity and sulfotransferase activity. Involved in dendrite arborization. Predicted to be located in cytosol and mitochondrion. Predicted to be active in cytoplasm. Orthologous to human SULT4A1 (sulfotransferase family 4A member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 404.1) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sult4a1 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (117096064..117120714, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (115216066..115240156, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (124958546..124982602, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene EF-hand calcium binding domain 6 Neighboring gene uncharacterized LOC120093701 Neighboring gene uncharacterized LOC134479758 Neighboring gene patatin-like phospholipase domain containing 5 Neighboring gene patatin-like phospholipase domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. SULT4A1 Modulates Synaptic Development and Function by Promoting the Formation of PSD-95/NMDAR Complex. Culotta L, et al. J Neurosci, 2020 Sep 9. PMID 32801157, Free PMC Article
    2. Molecular cloning and expression of novel sulphotransferase-like cDNAs from human and rat brain. Falany CN, et al. Biochem J, 2000 Mar 15. PMID 10698717, Free PMC Article
    3. Cytosolic Aryl sulfotransferase 4A1 interacts with the peptidyl prolyl cis-trans isomerase Pin1. Mitchell DJ, et al. Mol Pharmacol, 2009 Aug. PMID 19439498
    4. Highly conserved mouse and human brain sulfotransferases: molecular cloning, expression, and functional characterization. Sakakibara Y, et al. Gene, 2002 Feb 20. PMID 12039030
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in dendrite arborization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sulfation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sulfur compound metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sulfotransferase 4A1
    Names
    NST
    brain sulfotransferase-like protein
    nervous system sulfotransferase
    rBR-STL
    sulfotransferase-related protein
    NP_113829.1
    XP_017450556.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031641.2 → NP_113829.1  sulfotransferase 4A1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      P63047
      UniProtKB/TrEMBL
      A6HTA9, A6HTB0
      Related
      ENSRNOP00000066760.1, ENSRNOT00000075099.4
      Conserved Domains (1) summary
      pfam00685
      Location:45 → 277
      Sulfotransfer_1; Sulfotransferase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      117096064..117120714 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017595067.3 → XP_017450556.1  sulfotransferase 4A1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AMX8, A6HTB1
      Related
      ENSRNOP00000094830.1, ENSRNOT00000115395.2
      Conserved Domains (1) summary
      pfam00685
      Location:45 → 230
      Sulfotransfer_1; Sulfotransferase domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P63047.1 GenPept UniProtKB/Swiss-Prot:P63047

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
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