S1pr1 sphingosine-1-phosphate receptor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: S1pr1provided by RGD
Official Full Name: sphingosine-1-phosphate receptor 1provided by RGD
Primary source: RGD:61958
See related: EnsemblRapid:ENSRNOG00000013683 AllianceGenome:RGD:61958
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Edg1
Summary: Enables G protein-coupled receptor activity and sphingolipid binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; negative regulation of stress fiber assembly; and positive regulation of GTPase activity. Predicted to be located in external side of plasma membrane and nucleoplasm. Predicted to be active in cytoplasm; plasma membrane; and presynapse. Used to study hypertension. Orthologous to human S1PR1 (sphingosine-1-phosphate receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 299.1), Spleen (RPKM 279.3) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q42

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (206309715..206314070, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (203624752..203629110, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (218654406..218658761, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LINC00707 inhibits myocardial fibrosis and immune disorder in rheumatic heart disease by regulating miR-145-5p/S1PR1.
Title: LINC00707 inhibits myocardial fibrosis and immune disorder in rheumatic heart disease by regulating miR-145-5p/S1PR1.
Long non-coding RNA HOX transcript antisense intergenic RNA depletion protects against alcoholic hepatitis through the microRNA-148a-3p/sphingosine 1-phosphate receptor 1 axis.
Title: Long non-coding RNA HOX transcript antisense intergenic RNA depletion protects against alcoholic hepatitis through the microRNA-148a-3p/sphingosine 1-phosphate receptor 1 axis.
The GPCR adaptor protein Norbin regulates S1PR1 trafficking and the morphology, cell cycle and survival of PC12 cells.
Title: The GPCR adaptor protein Norbin regulates S1PR1 trafficking and the morphology, cell cycle and survival of PC12 cells.
Role of Adenosine Kinase in Sphingosine-1-Phosphate Receptor 1-Induced Mechano-Hypersensitivities.
Title: Role of Adenosine Kinase in Sphingosine-1-Phosphate Receptor 1-Induced Mechano-Hypersensitivities.
The S1PR1 agonist SEW2871 promotes the survival of skin flap.
Title: The S1PR1 agonist SEW2871 promotes the survival of skin flap.
Dysregulated zinc and sphingosine-1-phosphate signaling in pulmonary hypertension: Potential effects by targeting of bone morphogenetic protein receptor type 2 in pulmonary microvessels.
Title: Dysregulated zinc and sphingosine-1-phosphate signaling in pulmonary hypertension: Potential effects by targeting of bone morphogenetic protein receptor type 2 in pulmonary microvessels.
Interference with the expression of S1PR1 or STAT3 attenuates valvular damage due to rheumatic heart disease.
Title: Interference with the expression of S1PR1 or STAT3 attenuates valvular damage due to rheumatic heart disease.
miR-140 ameliorates neuropathic pain in CCI rats by targeting S1PR1.
Title: miR-140 ameliorates neuropathic pain in CCI rats by targeting S1PR1.
A G protein-biased S1P1 agonist, SAR247799, protects endothelial cells without affecting lymphocyte numbers.
Title: A G protein-biased S1P(1) agonist, SAR247799, protects endothelial cells without affecting lymphocyte numbers.
In Vitro and In Vivo Investigation of S1PR1 Expression in the Central Nervous System Using [(3)H]CS1P1 and [(11)C]CS1P1.
Title: InVitro and In Vivo Investigation of S1PR1 Expression in the Central Nervous System Using [(3)H]CS1P1 and [(11)C]CS1P1.

Submit: New GeneRIF Correction See all GeneRIFs (38)

General gene information

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Markers

EDG1 (e-PCR)
- UniSTS:266357

RH129877 (e-PCR)
- UniSTS:213165

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables G protein-coupled receptor activity	TAS Traceable Author Statement more info	PubMed
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info
enables sphingolipid binding	IDA Inferred from Direct Assay more info	PubMed
enables sphingosine-1-phosphate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables sphingosine-1-phosphate receptor activity	ISO Inferred from Sequence Orthology more info
enables sphingosine-1-phosphate receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in T cell migration	ISO Inferred from Sequence Orthology more info
involved_in T cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in blood vessel maturation	ISO Inferred from Sequence Orthology more info
involved_in blood vessel maturation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within brain development	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle tissue growth involved in heart morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle tissue growth involved in heart morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in endothelial cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in heart trabecula morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in heart trabecula morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in lamellipodium assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within leukocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of stress fiber assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of positive chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of smooth muscle cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in regulation of bone mineralization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of bone resorption	ISO Inferred from Sequence Orthology more info
involved_in regulation of bone resorption	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sphingosine-1-phosphate receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in sphingosine-1-phosphate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in sphingosine-1-phosphate receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in transmission of nerve impulse	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sphingosine 1-phosphate receptor 1

Names: EDG1 (Edg1); S1P receptor 1; S1P receptor Edg-1; S1P1; endothelial differentiation G-protein coupled receptor 1; endothelial differentiation sphingolipid G-protein-coupled receptor 1; sphingosine 1-phosphate receptor Edg-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017301.2 → NP_058997.1 sphingosine 1-phosphate receptor 1

See identical proteins and their annotated locations for NP_058997.1

Status: PROVISIONAL

Source sequence(s)

BC097938

UniProtKB/Swiss-Prot

P48303, Q4V7F6

UniProtKB/TrEMBL

A6HV78

Related

ENSRNOP00000098635.1, ENSRNOT00000142036.1

Conserved Domains (1) summary

cd15346
Location:47 → 323

7tmA_S1PR1_Edg1; sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

206309715..206314070 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008761459.4 → XP_008759681.1 sphingosine 1-phosphate receptor 1 isoform X1

See identical proteins and their annotated locations for XP_008759681.1

UniProtKB/Swiss-Prot

P48303, Q4V7F6

UniProtKB/TrEMBL

A6HV78

Related

ENSRNOP00000052627.1, ENSRNOT00000018318.5

Conserved Domains (1) summary

cd15346
Location:47 → 323

7tmA_S1PR1_Edg1; sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors