Kcnab1 potassium voltage-gated channel subfamily A regulatory beta subunit 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnab1provided by RGD
Official Full Name: potassium voltage-gated channel subfamily A regulatory beta subunit 1provided by RGD
Primary source: RGD:61827
See related: EnsemblRapid:ENSRNOG00000056697 AllianceGenome:RGD:61827
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: KvBeta3
Summary: Enables aldo-keto reductase (NADPH) activity; potassium channel regulator activity; and transmembrane transporter binding activity. Involved in several processes, including myoblast differentiation; negative regulation of delayed rectifier potassium channel activity; and skeletal muscle organ development. Located in dendrite; juxtaparanode region of axon; and perikaryon. Part of voltage-gated potassium channel complex. Biomarker of hypertension. Human ortholog(s) of this gene implicated in temporal lobe epilepsy. Orthologous to human KCNAB1 (potassium voltage-gated channel subfamily A regulatory beta subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 185.6), Uterus (RPKM 34.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q31

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (151446975..151913636)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (149137025..149603540)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (155555798..156011438)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The potassium channel subunit Kvbeta1 serves as a major control point for synaptic facilitation.
Title: The potassium channel subunit K(v)β1 serves as a major control point for synaptic facilitation.
cofactor oxidation by Kvbeta1 is regulated by membrane potential, presumably via voltage-dependent structural changes in Kv1.1 channels.
Title: Functional coupling between the Kv1.1 channel and aldoketoreductase Kvbeta1.
The potassium channel subunit Kvbeta3 interacts with pannexin 1 and attenuates its sensitivity to changes in redox potentials.
Title: The potassium channel subunit Kvbeta3 interacts with pannexin 1 and attenuates its sensitivity to changes in redox potentials.
A structural model of fatty acid (lithocholate) insertion and docking onto specific Kcnab1 transmembrane domain 2 interface regions is postulated that explains the differential efficacy of bile acids on large channel activity.
Title: Structural determinants of monohydroxylated bile acids to activate beta 1 subunit-containing BK channels.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU049268 (e-PCR)
- UniSTS:145716

BE119701 (e-PCR)
- UniSTS:249252

D2Rat38 (e-PCR)
- UniSTS:118695

AU047443 (e-PCR)
- UniSTS:110504

BE119763 (e-PCR)
- UniSTS:249261

D2Rat374 (e-PCR), detects polymorphism
- UniSTS:227508

BE097574 (e-PCR)
- UniSTS:244695

D2Got107 (e-PCR)
- UniSTS:114936

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NADPH binding	IEA Inferred from Electronic Annotation more info
enables NADPH binding	ISO Inferred from Sequence Orthology more info
enables NADPH binding	ISS Inferred from Sequence or Structural Similarity more info
enables aldo-keto reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables aldo-keto reductase (NADPH) activity	IDA Inferred from Direct Assay more info	PubMed
enables carbonyl reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables molecular function inhibitor activity	IEA Inferred from Electronic Annotation more info
enables molecular function inhibitor activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables potassium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables potassium channel regulator activity	IEA Inferred from Electronic Annotation more info
enables potassium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in diaphragm development	IEP Inferred from Expression Pattern more info	PubMed
involved_in heart development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within learning or memory	ISO Inferred from Sequence Orthology more info
involved_in myoblast differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of delayed rectifier potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of delayed rectifier potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of delayed rectifier potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of potassium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle tissue development	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in juxtaparanode region of axon	IBA Inferred from Biological aspect of Ancestor more info
located_in juxtaparanode region of axon	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of potassium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of potassium channel complex	ISO Inferred from Sequence Orthology more info
located_in proximal dendrite	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	IEA Inferred from Electronic Annotation more info
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: voltage-gated potassium channel subunit beta-1

Names: K(+) channel subunit beta-1; Kvbeta1.1; Kvbeta1.2; Kvbeta1.3; kv-beta-1; potassium channel, voltage gated subfamily A regulatory beta subunit 1; potassium channel, voltage-gated shaker related subfamily A regulatory beta subunit 1; potassium voltage-gated channel subfamily A member regulatory beta subunit 1; potassium voltage-gated channel, shaker-related subfamily, beta member 1; voltage-gated potassium channel beta subunit

NP_058999.1

EC 1.1.1.-

XP_017446287.1

EC 1.1.1.-

XP_038958053.1

EC 1.1.1.-

XP_063137750.1

EC 1.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017303.3 → NP_058999.1 voltage-gated potassium channel subunit beta-1

See identical proteins and their annotated locations for NP_058999.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

P63144, Q5FWS9

UniProtKB/TrEMBL

A6J5J1

Related

ENSRNOP00000072289.1, ENSRNOT00000077973.3

Conserved Domains (1) summary

cd19159
Location:71 → 393

AKR_KCAB1B_AKR6A3-like; voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

151446975..151913636

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017590798.3 → XP_017446287.1 voltage-gated potassium channel subunit beta-1 isoform X1

UniProtKB/TrEMBL

A0A8I6AJY2

Related

ENSRNOP00000095564.1, ENSRNOT00000120207.2
XM_063281680.1 → XP_063137750.1 voltage-gated potassium channel subunit beta-1 isoform X3
XM_039102125.2 → XP_038958053.1 voltage-gated potassium channel subunit beta-1 isoform X2

UniProtKB/TrEMBL

A0A8I5Y1W3

Related

ENSRNOP00000078062.1, ENSRNOT00000097545.2

Conserved Domains (1) summary

cd19159
Location:78 → 400

AKR_KCAB1B_AKR6A3-like; voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins