Cfap418 cilia and flagella associated protein 418 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cfap418provided by RGD
Official Full Name: cilia and flagella associated protein 418provided by RGD
Primary source: RGD:1549749
See related: EnsemblRapid:ENSRNOG00000026672 AllianceGenome:RGD:1549749
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in photoreceptor cell morphogenesis. Predicted to be located in several cellular components, including cell junction; ciliary base; and photoreceptor inner segment. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 21 and cone-rod dystrophy 16. Orthologous to human CFAP418 (cilia and flagella associated protein 418). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 128.5), Brain (RPKM 92.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q13

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (28789580..28812891)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (23996395..24015609)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (23358464..23377697) , (24145829..24165467)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH132804 (e-PCR)
- UniSTS:216087

RH137584 (e-PCR)
- UniSTS:219671

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in photoreceptor cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in photoreceptor cell morphogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in ciliary base	IEA Inferred from Electronic Annotation more info
located_in ciliary base	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in photoreceptor inner segment	IEA Inferred from Electronic Annotation more info
located_in photoreceptor inner segment	ISO Inferred from Sequence Orthology more info
located_in photoreceptor inner segment	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cilia- and flagella-associated protein 418

Names: protein C8orf37 homolog; uncharacterized protein C8orf37 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007746.1 → NP_001007747.1 cilia- and flagella-associated protein 418 isoform 1

See identical proteins and their annotated locations for NP_001007747.1

Status: PROVISIONAL

Source sequence(s)

BC079168

UniProtKB/Swiss-Prot

Q6AY71

UniProtKB/TrEMBL

A6JFS0

Related

ENSRNOP00000034206.5, ENSRNOT00000037547.5

Conserved Domains (1) summary

pfam14996
Location:65 → 210

RMP; Retinal Maintenance
NM_001429152.1 → NP_001416081.1 cilia- and flagella-associated protein 418 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A8L2QK72

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

28789580..28812891

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006237871.4 → XP_006237933.1 cilia- and flagella-associated protein 418 isoform X2

Related

ENSRNOP00000098817.1, ENSRNOT00000160190.1

Conserved Domains (1) summary

pfam14996
Location:65 → 211

RMP; Retinal Maintenance
XM_063287899.1 → XP_063143969.1 cilia- and flagella-associated protein 418 isoform X1