Lamb1 laminin subunit beta 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lamb1provided by RGD
Official Full Name: laminin subunit beta 1provided by RGD
Primary source: RGD:1306311
See related: EnsemblRapid:ENSRNOG00000005678 AllianceGenome:RGD:1306311
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lamb1-1
Summary: Predicted to enable enzyme binding activity; glycosphingolipid binding activity; and integrin binding activity. Predicted to be a structural constituent of synapse-associated extracellular matrix. Predicted to be an extracellular matrix structural constituent. Predicted to be involved in several processes, including basement membrane assembly; neurogenesis; and substrate adhesion-dependent cell spreading. Predicted to act upstream of or within embryo implantation and neuron projection development. Located in collagen-containing extracellular matrix. Human ortholog(s) of this gene implicated in autistic disorder and lissencephaly 5. Orthologous to human LAMB1 (laminin subunit beta 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 633.1), Kidney (RPKM 484.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q16

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (53562849..53630118)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (47835492..47902585)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (50528796..50596593)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of endogenous laminin-B1 expression using RNA interference (LB1 siRNA) enhanced water maze performance.
Title: Laminin-β1 impairs spatial learning through inhibition of ERK/MAPK and SGK1 signaling.
Binding sites for alpha3beta1 and alpha6beta4 are closely spaced in the Ln-332 LG domains where they regulate alternative cell functions, namely adhesion/migration or hemidesmosome anchoring.
Title: Epitope mapping of function-blocking monoclonal antibody CM6 suggests a "weak" integrin binding site on the laminin-332 LG2 domain.
Manifestation of laminin immunoreactivity indicates gliovascular decoupling afgter traumatic brain injury.
Title: Post traumatic lesion absence of beta-dystroglycan-immunopositivity in brain vessels coincides with the glial reaction and the immunoreactivity of vascular laminin.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH137828 (e-PCR)
- UniSTS:219915

UniSTS:236828 (e-PCR)
- UniSTS:236828

RH126801 (e-PCR)
- UniSTS:208795

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables extracellular matrix structural constituent	ISO Inferred from Sequence Orthology more info
enables glycosphingolipid binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in basement membrane assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in biological_process	ND No biological Data available more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryo implantation	ISO Inferred from Sequence Orthology more info
involved_in endodermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neuronal-glial interaction involved in cerebral cortex radial glia guided migration	ISO Inferred from Sequence Orthology more info
involved_in odontogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in substrate adhesion-dependent cell spreading	IBA Inferred from Biological aspect of Ancestor more info
involved_in substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in tissue development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in basement membrane	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of laminin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of laminin complex	ISO Inferred from Sequence Orthology more info
part_of laminin-1 complex	ISO Inferred from Sequence Orthology more info
part_of laminin-10 complex	ISO Inferred from Sequence Orthology more info
part_of laminin-2 complex	ISO Inferred from Sequence Orthology more info
part_of laminin-8 complex	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: laminin subunit beta-1

Names: laminin B1 subunit 1; laminin, beta 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106721.2 → NP_001100191.2 laminin subunit beta-1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A8I6A3T2, D3ZQN7

Related

ENSRNOP00000008321.7, ENSRNOT00000008321.9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

53562849..53630118

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063261658.1 → XP_063117728.1 laminin subunit beta-1 isoform X2

UniProtKB/TrEMBL

A0A8I6A3T2, D3ZQN7
XM_003750137.6 → XP_003750185.1 laminin subunit beta-1 isoform X1

UniProtKB/TrEMBL

A0A8I5ZQ25, A0A8I6A3T2

Related

ENSRNOP00000080442.1, ENSRNOT00000095840.2

Conserved Domains (8) summary

smart00180
Location:821 → 866

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00283
Location:1500 → 1739

MA; Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer)

cd00055
Location:505 → 556

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

pfam00053
Location:869 → 917

Laminin_EGF; Laminin EGF domain

pfam00055
Location:92 → 317

Laminin_N; Laminin N-terminal (Domain VI)

cl09111
Location:1654 → 1768

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

cl23720
Location:1738 → 1826

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

cl23763
Location:1504 → 1706

MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain
XM_006239997.5 → XP_006240059.1 laminin subunit beta-1 isoform X2

See identical proteins and their annotated locations for XP_006240059.1

UniProtKB/TrEMBL

A0A8I6A3T2, D3ZQN7

Conserved Domains (8) summary

smart00180
Location:773 → 818

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00283
Location:1452 → 1691

MA; Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer)

cd00055
Location:457 → 508

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

pfam00053
Location:821 → 869

Laminin_EGF; Laminin EGF domain

pfam00055
Location:44 → 269

Laminin_N; Laminin N-terminal (Domain VI)

cl09111
Location:1606 → 1720

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

cl23720
Location:1690 → 1778

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

cl23763
Location:1456 → 1658

MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain