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    Hectd4 HECT domain E3 ubiquitin protein ligase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304503, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hectd4provided by RGD
    Official Full Name
    HECT domain E3 ubiquitin protein ligase 4provided by RGD
    Primary source
    RGD:1309762
    See related
    EnsemblRapid:ENSRNOG00000001352 AllianceGenome:RGD:1309762
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309762
    Summary
    Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in glucose homeostasis and glucose metabolic process. Orthologous to human HECTD4 (HECT domain E3 ubiquitin protein ligase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 134.0), Brain (RPKM 127.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hectd4 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    79
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (40800232..40991584, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (35182165..35330935, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (40712078..40860930, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095847 Neighboring gene endoplasmic reticulum protein 29 Neighboring gene N(alpha)-acetyltransferase 25, NatB auxiliary subunit Neighboring gene 40S ribosomal protein S27-like Neighboring gene 40S ribosomal protein S20-like Neighboring gene TRAF type zinc finger domain containing 1 Neighboring gene small nucleolar RNA SNORA42/SNORA80 family Neighboring gene ribosomal protein L6 Neighboring gene protein tyrosine phosphatase, non-receptor type 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Weakened Interaction Between HECTD4 and GluN2B in Ischemic Stroke Promotes Calcium Overload and Brain Injury Through a Mechanism Involving the Decrease of GluN2B and MALT1 Ubiquitination. Zhang YY, et al. Mol Neurobiol, 2023 Mar. PMID 36527595
    2. New susceptibility loci in MYL2, C12orf51 and OAS1 associated with 1-h plasma glucose as predisposing risk factors for type 2 diabetes in the Korean population. Go MJ, et al. J Hum Genet, 2013 Jun. PMID 23575436
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Weakened Interaction Between HECTD4 and GluN2B in Ischemic Stroke Promotes Calcium Overload and Brain Injury Through a Mechanism Involving the Decrease of GluN2B and MALT1 Ubiquitination.
      Title: The Weakened Interaction Between HECTD4 and GluN2B in Ischemic Stroke Promotes Calcium Overload and Brain Injury Through a Mechanism Involving the Decrease of GluN2B and MALT1 Ubiquitination.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glucose homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    probable E3 ubiquitin-protein ligase HECTD4
    Names
    HECT domain containing E3 ubiquitin protein ligase 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      40800232..40991584 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089874.2 → XP_038945802.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZZM0
      Conserved Domains (2) summary
      cd13735
      Location:2413 → 2568
      SPRY_HECT_like; SPRY domain in HECT E3
      cl27008
      Location:4033 → 4426
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    2. XM_039089873.2 → XP_038945801.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZZM0
      Conserved Domains (2) summary
      cd13735
      Location:2414 → 2569
      SPRY_HECT_like; SPRY domain in HECT E3
      cl27008
      Location:4033 → 4426
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    3. XM_017598533.3 → XP_017454022.2  probable E3 ubiquitin-protein ligase HECTD4 isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZZM0
      Conserved Domains (2) summary
      cd13735
      Location:2398 → 2553
      SPRY_HECT_like; SPRY domain in HECT E3
      cl27008
      Location:4018 → 4411
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    4. XM_063271893.1 → XP_063127963.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZZM0

    5. XM_039089875.2 → XP_038945803.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZZM0
      Conserved Domains (2) summary
      cd13735
      Location:2412 → 2567
      SPRY_HECT_like; SPRY domain in HECT E3
      cl27008
      Location:4032 → 4425
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    6. XM_039089878.2 → XP_038945806.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZZM0
      Conserved Domains (2) summary
      cd13735
      Location:2400 → 2555
      SPRY_HECT_like; SPRY domain in HECT E3
      cl27008
      Location:4020 → 4413
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    7. XM_039089877.2 → XP_038945805.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZZM0
      Related
      ENSRNOP00000084673.2, ENSRNOT00000109636.2
      Conserved Domains (2) summary
      cd13735
      Location:2405 → 2560
      SPRY_HECT_like; SPRY domain in HECT E3
      cl27008
      Location:4025 → 4418
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    8. XM_039089876.2 → XP_038945804.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZZM0
      Conserved Domains (2) summary
      cd13735
      Location:2409 → 2564
      SPRY_HECT_like; SPRY domain in HECT E3
      cl27008
      Location:4029 → 4422
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    9. XM_039089872.2 → XP_038945800.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZZM0
      Conserved Domains (2) summary
      cd13735
      Location:2414 → 2569
      SPRY_HECT_like; SPRY domain in HECT E3
      cl27008
      Location:4034 → 4427
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    10. XM_039089879.2 → XP_038945807.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X10

      UniProtKB/TrEMBL
      F1LZX5
      Conserved Domains (2) summary
      cd13735
      Location:1888 → 2043
      SPRY_HECT_like; SPRY domain in HECT E3
      cl27008
      Location:3508 → 3901
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    11. XM_039089880.2 → XP_038945808.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X11

      UniProtKB/TrEMBL
      F1LZX5
      Conserved Domains (2) summary
      cd13735
      Location:1370 → 1525
      SPRY_HECT_like; SPRY domain in HECT E3
      cl27008
      Location:2990 → 3383
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    12. XM_039089882.1 → XP_038945810.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X12

      Conserved Domains (2) summary
      cd13735
      Location:930 → 1085
      SPRY_HECT_like; SPRY domain in HECT E3
      cl27008
      Location:2550 → 2943
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    RNA

    1. XR_010056783.1 RNA Sequence

    2. XR_010056782.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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