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    Donson DNA replication fork stabilization factor DONSON [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288257, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Donsonprovided by RGD
    Official Full Name
    DNA replication fork stabilization factor DONSONprovided by RGD
    Primary source
    RGD:1306823
    See related
    EnsemblRapid:ENSRNOG00000002012 AllianceGenome:RGD:1306823
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in DNA-templated DNA replication and mitotic G2/M transition checkpoint. Predicted to be located in replication fork. Predicted to be part of replisome. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in microcephaly, short stature, and limb abnormalities and microcephaly-micromelia syndrome. Orthologous to human DONSON (DNA replication fork stabilization factor DONSON). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 98.3), Spleen (RPKM 83.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Donson in Genome Data Viewer
    Location:
    11q11
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (44405794..44419099, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (30919834..30933150, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (31834608..31847751, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C28 Neighboring gene SON DNA and RNA binding protein Neighboring gene phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase Neighboring gene crystallin zeta like 1 Neighboring gene intersectin 1 Neighboring gene uncharacterized LOC134481057 Neighboring gene ATP synthase peripheral stalk subunit OSCP

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism. Reynolds JJ, et al. Nat Genet, 2017 Apr. PMID 28191891, Free PMC Article
    2. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94546

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic DNA replication checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic G2 DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in replication fork processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in replication fork ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of replisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein downstream neighbor of Son
    Names
    downstream neighbor of SON

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008287.2 → NP_001008288.2  protein downstream neighbor of Son isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      E9PSU2, Q5U2V7

    2. NM_001399266.1 → NP_001386195.1  protein downstream neighbor of Son isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A8I6ACX2, A6JLH3, Q5U2V7
      Related
      ENSRNOP00000089568.2, ENSRNOT00000093955.2
      Conserved Domains (1) summary
      PHA03378
      Location:6 → 102
      PHA03378; EBNA-3B; Provisional

    3. NM_001399267.1 → NP_001386196.1  protein downstream neighbor of Son isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A8I6ACX2, A6JLH3, Q5U2V7
      Related
      ENSRNOP00000058017.3, ENSRNOT00000061304.5
      Conserved Domains (1) summary
      PHA03378
      Location:6 → 102
      PHA03378; EBNA-3B; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      44405794..44419099 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270426.1 → XP_063126496.1  protein downstream neighbor of Son isoform X4

      UniProtKB/TrEMBL
      Q5U2V7

    2. XM_063270424.1 → XP_063126494.1  protein downstream neighbor of Son isoform X2

      UniProtKB/TrEMBL
      Q5U2V7

    3. XM_017597940.2 → XP_017453429.1  protein downstream neighbor of Son isoform X2

      UniProtKB/TrEMBL
      Q5U2V7

    4. XM_063270425.1 → XP_063126495.1  protein downstream neighbor of Son isoform X3

      UniProtKB/TrEMBL
      E9PSU2, Q5U2V7

    5. XM_017597939.3 → XP_017453428.1  protein downstream neighbor of Son isoform X1

      UniProtKB/TrEMBL
      A0A8I6ACX2, A6JLH3, Q5U2V7
      Conserved Domains (1) summary
      PHA03378
      Location:6 → 102
      PHA03378; EBNA-3B; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version

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