Dhx37 DEAH-box helicase 37 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dhx37provided by RGD
Official Full Name: DEAH-box helicase 37provided by RGD
Primary source: RGD:1306837
See related: EnsemblRapid:ENSRNOG00000022171 AllianceGenome:RGD:1306837
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable U3 snoRNA binding activity and helicase activity. Predicted to be involved in brain development; positive regulation of male gonad development; and ribosome biogenesis. Predicted to be located in cytoplasm and nuclear membrane. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Human ortholog(s) of this gene implicated in 46,XY sex reversal. Orthologous to human DHX37 (DEAH-box helicase 37). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 46.0), Thymus (RPKM 42.4) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 12q14

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (36856119..36876245)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (31194782..31214890)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (36594058..36614165)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables U3 snoRNA binding	ISO Inferred from Sequence Orthology more info
enables helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in brain development	ISO Inferred from Sequence Orthology more info
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of male gonad development	ISO Inferred from Sequence Orthology more info
involved_in ribosomal small subunit biogenesis	ISO Inferred from Sequence Orthology more info
involved_in ribosome assembly	ISO Inferred from Sequence Orthology more info
involved_in ribosome biogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
part_of small-subunit processome	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: probable ATP-dependent RNA helicase DHX37

Names: DEAH (Asp-Glu-Ala-His) box polypeptide 37

NP_001099396.2

EC 3.6.4.13

XP_063127240.1

EC 3.6.4.13

XP_063127241.1

EC 3.6.4.13

XP_063127242.1

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105926.2 → NP_001099396.2 probable ATP-dependent RNA helicase DHX37

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

D4A1R0

Related

ENSRNOP00000038631.4, ENSRNOT00000030823.8

Conserved Domains (6) summary

smart00490
Location:578 → 667

HELICc; helicase superfamily c-terminal domain

smart00847
Location:761 → 852

HA2; Helicase associated domain (HA2) Add an annotation

COG1643
Location:236 → 1009

HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

cd00046
Location:267 → 407

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam04408
Location:730 → 781

HA2; Helicase associated domain (HA2)

pfam07717
Location:887 → 1004

OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

36856119..36876245

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063271170.1 → XP_063127240.1 probable ATP-dependent RNA helicase DHX37 isoform X1
XM_063271172.1 → XP_063127242.1 probable ATP-dependent RNA helicase DHX37 isoform X3

UniProtKB/TrEMBL

A6J0W5
XM_063271171.1 → XP_063127241.1 probable ATP-dependent RNA helicase DHX37 isoform X2