Stim2 stromal interaction molecule 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Stim2provided by RGD
Official Full Name: stromal interaction molecule 2provided by RGD
Primary source: RGD:1304641
See related: EnsemblRapid:ENSRNOG00000002956 AllianceGenome:RGD:1304641
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables calcium channel regulator activity. Involved in activation of store-operated calcium channel activity. Predicted to be active in endoplasmic reticulum and plasma membrane. Orthologous to human STIM2 (stromal interaction molecule 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 67.9), Brain (RPKM 53.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q11

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (61091550..61217281, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (56878428..57004405, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (59198180..59323947, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

STIM2 variants regulate Orai1/TRPC1/TRPC4-mediated store-operated Ca[2+] entry and mitochondrial Ca[2+] homeostasis in cardiomyocytes.
Title: STIM2 variants regulate Orai1/TRPC1/TRPC4-mediated store-operated Ca(2+) entry and mitochondrial Ca(2+) homeostasis in cardiomyocytes.
STIM1, STIM2, and PDI Participate in Cellular Fate Decisions in Low Energy Availability Induced by 3-NP in Male Rats.
Title: STIM1, STIM2, and PDI Participate in Cellular Fate Decisions in Low Energy Availability Induced by 3-NP in Male Rats.
STIM Protein-NMDA2 Receptor Interaction Decreases NMDA-Dependent Calcium Levels in Cortical Neurons.
Title: STIM Protein-NMDA2 Receptor Interaction Decreases NMDA-Dependent Calcium Levels in Cortical Neurons.
conclude that sub-lethal levels of proteasome inhibition reduce store-operated calcium entry and promote autophagy-mediated degradation of STIM1/2
Title: Inhibition of store-operated calcium entry by sub-lethal levels of proteasome inhibition is associated with STIM1/STIM2 degradation.
STIM2 promotes cAMP-dependent surface delivery of GluA1 through combined effects on exocytosis and endocytosis.
Title: STIM2 regulates PKA-dependent phosphorylation and trafficking of AMPARs.
TRPC2, by regulating STIM2, PKC expression, and SERCA activity, regulates calcium homeostasis in thyroid cells.
Title: Canonical transient receptor potential channel 2 (TRPC2) as a major regulator of calcium homeostasis in rat thyroid FRTL-5 cells: importance of protein kinase C δ (PKCδ) and stromal interaction molecule 2 (STIM2).
Stim1 and Stim2 were increased in brains of chronic epileptic rodents and strongly expressed in hippocampal specimens from medial temporal lobe epilepsy patients.
Title: Store-operated calcium entry modulates neuronal network activity in a model of chronic epilepsy.
STIM1 mainly activates store-operated calcium entry, whereas STIM2 regulates resting Ca(2+) levels in the endoplasmic reticulum and Ca(2+) leakage with the additional involvement of STIM1.
Title: Differential roles for STIM1 and STIM2 in store-operated calcium entry in rat neurons.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:235180 (e-PCR)
- UniSTS:235180

BM387514 (e-PCR)
- UniSTS:261579

Stim1 (e-PCR), detects polymorphism
- UniSTS:233960

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium channel regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables store-operated calcium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of store-operated calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in activation of store-operated calcium channel activity	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in store-operated calcium entry	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: stromal interaction molecule 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105750.2 → NP_001099220.2 stromal interaction molecule 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

A6IJF3, D4A5X1

Related

ENSRNOP00000004006.7, ENSRNOT00000004006.9

Conserved Domains (3) summary

cd09574
Location:132 → 205

SAM_STIM2; SAM domain of STIM2 subfamily proteins

smart00454
Location:133 → 197

SAM; Sterile alpha motif

pfam16533
Location:348 → 445

SOAR; STIM1 Orai1-activating region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

61091550..61217281 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039091560.2 → XP_038947488.1 stromal interaction molecule 2 isoform X1

UniProtKB/TrEMBL

A0A8I6A6S4, A6IJF3, D4A5X1

Related

ENSRNOP00000087921.1, ENSRNOT00000119766.2

Conserved Domains (3) summary

cd09574
Location:198 → 271

SAM_STIM2; SAM domain of STIM2 subfamily proteins

COG1196
Location:304 → 513

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam16533
Location:414 → 519

SOAR; STIM1 Orai1-activating region
XM_039091561.2 → XP_038947489.1 stromal interaction molecule 2 isoform X2

UniProtKB/TrEMBL

A0A8I6AK33

Related

ENSRNOP00000089061.1, ENSRNOT00000113845.2

Conserved Domains (3) summary

cd09574
Location:103 → 176

SAM_STIM2; SAM domain of STIM2 subfamily proteins

COG1196
Location:209 → 418

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam16533
Location:319 → 424

SOAR; STIM1 Orai1-activating region
XM_039091563.2 → XP_038947491.1 stromal interaction molecule 2 isoform X5

Conserved Domains (3) summary

COG1196
Location:60 → 269

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam16533
Location:170 → 275

SOAR; STIM1 Orai1-activating region

cl15755
Location:1 → 27

SAM_superfamily; SAM (Sterile alpha motif )
XM_039091562.2 → XP_038947490.1 stromal interaction molecule 2 isoform X3

UniProtKB/TrEMBL

A0A8I6AK33

Conserved Domains (3) summary

cd09574
Location:13 → 85

SAM_STIM2; SAM domain of STIM2 subfamily proteins

COG1196
Location:118 → 327

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam16533
Location:228 → 333

SOAR; STIM1 Orai1-activating region
XM_063272807.1 → XP_063128877.1 stromal interaction molecule 2 isoform X4

UniProtKB/TrEMBL

A0A8I6AK33