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    Rell1 RELT-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289635, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rell1provided by RGD
    Official Full Name
    RELT-like 1provided by RGD
    Primary source
    RGD:1307468
    See related
    EnsemblRapid:ENSRNOG00000002192 AllianceGenome:RGD:1307468
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307468
    Summary
    Predicted to be involved in positive regulation of p38MAPK cascade. Predicted to be located in microtubule cytoskeleton. Predicted to be active in plasma membrane. Orthologous to human RELL1 (RELT like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 59.7), Adrenal (RPKM 54.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rell1 in Genome Data Viewer
    Location:
    14p11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (44672121..44732081)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (44318640..44378541)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (45982244..46041907)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene serine/threonine/tyrosine interacting protein, pseudogene 2 Neighboring gene uncharacterized LOC100911506 Neighboring gene similar to human chromosome 4 open reading frame 19 Neighboring gene NACHT and WD repeat domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RELT family members activate p38 and induce apoptosis by a mechanism distinct from TNFR1. Moua P, et al. Biochem Biophys Res Commun, 2017 Sep 9. PMID 28688764, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in positive regulation of p38MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in microtubule cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RELT-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113776.2 → NP_001107248.1  RELT-like protein 1 precursor

      See identical proteins and their annotated locations for NP_001107248.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A096MJ67, B0BNL7
      Conserved Domains (1) summary
      pfam12606
      Location:59 → 91
      RELT; tumor necrosis factor receptor superfamily member 19

    2. NM_001434391.1 → NP_001421320.1  RELT-like protein 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A096MJ67, B0BNL7

    3. NM_001434392.1 → NP_001421321.1  RELT-like protein 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A096MJ67, B0BNL7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      44672121..44732081
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250998.5 → XP_006251060.1  RELT-like protein 1 isoform X1

      Related
      ENSRNOP00000068475.1, ENSRNOT00000076881.4
      Conserved Domains (1) summary
      pfam12606
      Location:59 → 91
      RELT; tumor necrosis factor receptor superfamily member 19

    2. XM_039091719.2 → XP_038947647.1  RELT-like protein 1 isoform X1

      Conserved Domains (1) summary
      pfam12606
      Location:59 → 91
      RELT; tumor necrosis factor receptor superfamily member 19
    Nucleotide Protein Strain
    Heading Accession and Version

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