Dhh desert hedgehog signaling molecule [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dhhprovided by RGD
Official Full Name: desert hedgehog signaling moleculeprovided by RGD
Primary source: RGD:620711
See related: EnsemblRapid:ENSRNOG00000053675 AllianceGenome:RGD:620711
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable calcium ion binding activity; patched binding activity; and zinc ion binding activity. Involved in several processes, including response to estradiol; response to estrogen; and spermatid development. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in 46,XY sex reversal and 46,XY sex reversal 7. Orthologous to human DHH (desert hedgehog signaling molecule). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 39.9), Lung (RPKM 20.3) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q36

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (131929857..131935352, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (130050910..130056406, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (140575288..140580783, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GATA4/6 regulate DHH transcription in rat adrenocortical autografts.
Title: GATA4/6 regulate DHH transcription in rat adrenocortical autografts.
Dhh and Gli1 might function in concert to regenerate adrenocortical autografts. This is the first report to clearly show Dhh expression and its elevation in the adrenal gland.
Title: Involvement of DHH and GLI1 in adrenocortical autograft regeneration in rats.
Hh signalling is part of the paracrine signalling network in the rat testis. It promotes the survival of germ cells and is suppressed by FSH.
Title: Hedgehog signalling promotes germ cell survival in the rat testis.
A missense mutation of the Dhh gene is associated with male pseudohermaphroditic rats showing impaired Leydig cell development.
Title: A missense mutation of the Dhh gene is associated with male pseudohermaphroditic rats showing impaired Leydig cell development.
The antiandrogen flutamide interferes with Dhh signaling resulting in an impaired differentiation of the fetal Leydig cells.
Title: Antiandrogen exposure in utero disrupts expression of desert hedgehog and insulin-like factor 3 in the developing fetal rat testis.
Despite Ihh variability, the expressions of Dhh and Shh mRNA remained unchanged in early pregnancy.
Title: Expression of hedgehog family genes in the rat uterus during early pregnancy.
in silico analysis of rat Desert hedgehog and Indian hedgehog genes
Title: Identification and characterization of rat Desert hedgehog and Indian hedgehog genes in silico.

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General gene information

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Markers

Dhh (e-PCR), detects polymorphism
- UniSTS:142848

Dhh (e-PCR), detects polymorphism
- UniSTS:464666

AW529714 (e-PCR)
- UniSTS:261231

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables patched binding	IBA Inferred from Biological aspect of Ancestor more info
enables patched binding	ISO Inferred from Sequence Orthology more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Leydig cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in Schwann cell development	ISO Inferred from Sequence Orthology more info
involved_in cell fate specification	IBA Inferred from Biological aspect of Ancestor more info
involved_in intein-mediated protein splicing	IEA Inferred from Electronic Annotation more info
involved_in male gonad development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within male sex determination	ISO Inferred from Sequence Orthology more info
involved_in myelination	IEP Inferred from Expression Pattern more info	PubMed
involved_in myelination	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in paracrine signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein autoprocessing	IEA Inferred from Electronic Annotation more info
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of steroid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estrogen	IEP Inferred from Expression Pattern more info	PubMed
involved_in smoothened signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in smoothened signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in spermatid development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within spermatid development	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: desert hedgehog protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.