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    Runx1t1 RUNX1 partner transcriptional co-repressor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362489, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Runx1t1provided by RGD
    Official Full Name
    RUNX1 partner transcriptional co-repressor 1provided by RGD
    Primary source
    RGD:1305490
    See related
    EnsemblRapid:ENSRNOG00000005673 AllianceGenome:RGD:1305490
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cbfa2t1
    Summary
    Predicted to enable DNA-binding transcription factor binding activity; identical protein binding activity; and transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription and negative regulation of fat cell differentiation. Predicted to act upstream of or within fat cell differentiation and regulation of DNA-templated transcription. Predicted to be located in nuclear matrix and nucleoplasm. Predicted to be active in nucleus. Orthologous to human RUNX1T1 (RUNX1 partner transcriptional co-repressor 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Lung (RPKM 31.0), Brain (RPKM 29.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Runx1t1 in Genome Data Viewer
    Location:
    5q13
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (31984946..32136878)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (27187674..27338070)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (27284921..27440802)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene transfer RNA threonine (anticodon AGU) 10 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene RUNX1 partner transcriptional co-repressor 1 like Neighboring gene uncharacterized LOC134478936 Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Runx1t1 regulates the neuronal differentiation of radial glial cells from the rat hippocampus. Linqing Z, et al. Stem Cells Transl Med, 2015 Jan. PMID 25473084, Free PMC Article
    2. Mutational analysis of RUNX1T1 gene in acute leukemias, breast and lung carcinomas. Kim YR, et al. Leuk Res, 2011 Sep. PMID 21571369
    3. ETO/MTG8 is an inhibitor of C/EBPbeta activity and a regulator of early adipogenesis. Rochford JJ, et al. Mol Cell Biol, 2004 Nov. PMID 15509789, Free PMC Article
    4. Atrophin-1, the dentato-rubral and pallido-luysian atrophy gene product, interacts with ETO/MTG8 in the nuclear matrix and represses transcription. Wood JD, et al. J Cell Biol, 2000 Sep 4. PMID 10973986, Free PMC Article
    5. Evolving New Skeletal Traits by cis-Regulatory Changes in Bone Morphogenetic Proteins. Indjeian VB, et al. Cell, 2016 Jan 14. PMID 26774823, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We have concluded that Runx1t1 could be involved in the process through which radial glial cells differentiate into neurons
      Title: Runx1t1 regulates the neuronal differentiation of radial glial cells from the rat hippocampus.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein CBFA2T1
    Names
    CBFA2T1 identified gene homolog
    RUNX1 translocation partner 1
    acute myelogenous leukemia 1 translocation 1 protein
    core-binding factor, runt domain, alpha subunit 2, translocated to, 1
    core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related
    cyclin D-related
    runt-related transcription factor 1
    runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
    translocated to, 1 (cyclin D-related)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108657.1 → NP_001102127.1  protein CBFA2T1

      Status: PROVISIONAL

      Source sequence(s)
      CH473962
      UniProtKB/TrEMBL
      A6II90, D3ZWZ8
      Related
      ENSRNOP00000063830.1, ENSRNOT00000066191.3
      Conserved Domains (4) summary
      COG1390
      Location:416 → 487
      NtpE; Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 [Energy production and conversion]
      pfam08788
      Location:310 → 376
      NHR2; NHR2 domain like
      pfam01753
      Location:488 → 524
      zf-MYND; MYND finger
      pfam07531
      Location:95 → 183
      TAFH; NHR1 homology to TAF

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      31984946..32136878
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237901.5 → XP_006237963.1  protein CBFA2T1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K0G0
      Conserved Domains (4) summary
      COG1390
      Location:443 → 514
      NtpE; Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 [Energy production and conversion]
      pfam08788
      Location:337 → 403
      NHR2; NHR2 domain like
      pfam01753
      Location:515 → 551
      zf-MYND; MYND finger
      pfam07531
      Location:122 → 210
      TAFH; NHR1 homology to TAF

    2. XM_006237904.5 → XP_006237966.1  protein CBFA2T1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6G5L4
      Related
      ENSRNOP00000081192.1, ENSRNOT00000111262.2
      Conserved Domains (5) summary
      TIGR02794
      Location:372 → 483
      tolA_full; TolA protein
      pfam01753
      Location:495 → 531
      zf-MYND; MYND finger
      pfam07531
      Location:102 → 188
      TAFH; NHR1 homology to TAF
      pfam08788
      Location:317 → 383
      NHR2; NHR2 domain like
      cl23750
      Location:421 → 477
      vATP-synt_E; ATP synthase (E/31 kDa) subunit

    3. XM_008763550.4 → XP_008761772.1  protein CBFA2T1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K0G0
      Related
      ENSRNOP00000090913.2, ENSRNOT00000094571.2
      Conserved Domains (4) summary
      COG1390
      Location:443 → 514
      NtpE; Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 [Energy production and conversion]
      pfam08788
      Location:337 → 403
      NHR2; NHR2 domain like
      pfam01753
      Location:515 → 551
      zf-MYND; MYND finger
      pfam07531
      Location:122 → 210
      TAFH; NHR1 homology to TAF

    4. XM_006237903.5 → XP_006237965.1  protein CBFA2T1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AB42
      Conserved Domains (4) summary
      COG1390
      Location:435 → 506
      NtpE; Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 [Energy production and conversion]
      pfam08788
      Location:329 → 395
      NHR2; NHR2 domain like
      pfam01753
      Location:507 → 543
      zf-MYND; MYND finger
      pfam07531
      Location:114 → 202
      TAFH; NHR1 homology to TAF

    5. XM_008763548.4 → XP_008761770.2  protein CBFA2T1 isoform X4

      UniProtKB/TrEMBL
      A6II91
      Related
      ENSRNOP00000071431.2, ENSRNOT00000078102.3
      Conserved Domains (4) summary
      COG1390
      Location:406 → 477
      NtpE; Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 [Energy production and conversion]
      pfam08788
      Location:300 → 366
      NHR2; NHR2 domain like
      pfam01753
      Location:478 → 514
      zf-MYND; MYND finger
      pfam07531
      Location:85 → 173
      TAFH; NHR1 homology to TAF

    6. XM_039110219.2 → XP_038966147.1  protein CBFA2T1 isoform X5

      Conserved Domains (3) summary
      COG1390
      Location:139 → 210
      NtpE; Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 [Energy production and conversion]
      pfam08788
      Location:33 → 99
      NHR2; NHR2 domain like
      pfam01753
      Location:211 → 247
      zf-MYND; MYND finger
    Nucleotide Protein Strain
    Heading Accession and Version

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