Ulk4 unc-51 like kinase 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ulk4provided by RGD
Official Full Name: unc-51 like kinase 4provided by RGD
Primary source: RGD:1565726
See related: EnsemblRapid:ENSRNOG00000019271 AllianceGenome:RGD:1565726
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565726
Summary: Predicted to enable ATP binding activity and protein kinase activity. Predicted to act upstream of or within several processes, including cilium organization; nervous system development; and regulation of MAPK cascade. Predicted to be located in extracellular region. Predicted to be active in cilium. Orthologous to human ULK4 (unc-51 like kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 50.1), Lung (RPKM 22.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 39

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (129548431..129843555, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (120670879..120966026, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (129631003..129919080, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within GABAergic neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adult behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adult walking behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axoneme assembly	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within brain development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within central nervous system myelination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cerebral cortex development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cerebrospinal fluid circulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ciliary basal body organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cognition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within corpus callosum development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dendritic spine development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within layer formation in cerebral cortex	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within learning or memory	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within memory	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within motile cilium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neurogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuroinflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuronal stem cell division	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein kinase C deactivation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pyramidal neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of neuron migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of p38MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of tau-protein kinase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within social behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ventricular system development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cilium	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/threonine-protein kinase ULK4

NP_001414641.1

EC 2.7.11.1

XP_038938659.1

EC 2.7.11.1

XP_038938660.1

EC 2.7.11.1

XP_038938662.1

EC 2.7.11.1

XP_038938664.1

EC 2.7.11.1

XP_038938665.1

EC 2.7.11.1

XP_063121919.1

EC 2.7.11.1

XP_063121920.1

EC 2.7.11.1

XP_063121921.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427712.1 → NP_001414641.1 serine/threonine-protein kinase ULK4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A8I6AHS6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

129548431..129843555 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039082734.2 → XP_038938662.1 serine/threonine-protein kinase ULK4 isoform X3

UniProtKB/TrEMBL

A0A8I6AHS6

Conserved Domains (2) summary

PLN00181
Location:185 → 398

PLN00181; protein SPA1-RELATED; Provisional

cd14010
Location:3 → 280

STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4
XM_039082731.2 → XP_038938659.1 serine/threonine-protein kinase ULK4 isoform X1

UniProtKB/TrEMBL

A0A8I6AHS6, M0R685

Related

ENSRNOP00000064927.3, ENSRNOT00000074423.5

Conserved Domains (2) summary

PLN00181
Location:185 → 489

PLN00181; protein SPA1-RELATED; Provisional

cd14010
Location:3 → 280

STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4
XM_063265850.1 → XP_063121920.1 serine/threonine-protein kinase ULK4 isoform X4

UniProtKB/TrEMBL

A0A8I6AHS6
XM_063265849.1 → XP_063121919.1 serine/threonine-protein kinase ULK4 isoform X2

UniProtKB/TrEMBL

A0A8I6AHS6
XM_039082732.2 → XP_038938660.1 serine/threonine-protein kinase ULK4 isoform X1

UniProtKB/TrEMBL

A0A8I6AHS6, M0R685

Conserved Domains (2) summary

PLN00181
Location:185 → 489

PLN00181; protein SPA1-RELATED; Provisional

cd14010
Location:3 → 280

STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4
XM_063265851.1 → XP_063121921.1 serine/threonine-protein kinase ULK4 isoform X5

UniProtKB/TrEMBL

A0A8I6AHS6
XM_039082737.2 → XP_038938665.1 serine/threonine-protein kinase ULK4 isoform X7
XM_039082736.2 → XP_038938664.1 serine/threonine-protein kinase ULK4 isoform X6

Conserved Domains (3) summary

PLN00181
Location:185 → 489

PLN00181; protein SPA1-RELATED; Provisional

cd14010
Location:3 → 280

STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4

cl02544
Location:670 → 752

VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily