Slc6a2 solute carrier family 6 member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc6a2provided by RGD
Official Full Name: solute carrier family 6 member 2provided by RGD
Primary source: RGD:621822
See related: EnsemblRapid:ENSRNOG00000016311 AllianceGenome:RGD:621822
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Net
Summary: Enables alpha-tubulin binding activity; beta-tubulin binding activity; and norepinephrine:sodium symporter activity. Involved in norepinephrine transport and response to xenobiotic stimulus. Located in cell surface. Is active in presynaptic membrane and synaptic vesicle membrane. Biomarker of depressive disorder. Human ortholog(s) of this gene implicated in alcohol dependence; hypertension; and neurocirculatory asthenia. Orthologous to human SLC6A2 (solute carrier family 6 member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 49.1), Lung (RPKM 13.1) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 19p11

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (30183289..30228292, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (14010292..14055317, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (15391682..15431274, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-181a and miR-29b can function as the negative regulators of norepinephrine transporter and glucocorticoid receptor translation in vitro
Title: MicroRNAs 29b and 181a down-regulate the expression of the norepinephrine transporter and glucocorticoid receptors in PC12 cells.
The findings of this study suggested that ENK and NET terminals in the BLa may interact by targeting common dendrites and by direct interactions between the two types of terminals.
Title: Light and electron microscopic analysis of enkephalin-like immunoreactivity in the basolateral amygdala, including evidence for convergence of enkephalin-containing axon terminals and norepinephrine transporter-containing axon terminals onto common targets.
These results demonstrate asymmetry in noradrenegic genes (Th, NET, and VMAT2) in the right and left stellate ganglia during stress and provide molecular evidence to help explain the difference in response to the stress.
Title: Differential expression of tyrosine hydroxylase and transporters in the right and left stellate ganglion of socially isolated rats.
norepinephrine transporter regulation occurs regionally in the heart and stellate ganglion in the hypertensive rat heart.
Title: Regional changes in cardiac and stellate ganglion norepinephrine transporter in DOCA-salt hypertension.
NK1R forms physical complexes with NET.
Title: Regulated norepinephrine transporter interaction with the neurokinin-1 receptor establishes transporter subcellular localization.
With social isolation, no changes were observed in protein levels of DBH and NET in the right hippocampus, whereas expression of this norepinephrine synthetizing enzyme and transporter were elevated in the left hippocampus.
Title: Hippocampal asymmetry in expression of catecholamine synthesizing enzyme and transporters in socially isolated rats.
role for nitric oxide in regulating the activity of the norepinephrine transporter
Title: In-vivo evidence of a role for nitric oxide in regulating the activity of the norepinephrine transporter.
The present study demonstrates an upregulatory effect of Phox2a and Phox2b on the expression of dopamine beta-hydroxylase and norepinephrine transporter in noradrenergic neurons of rat brains
Title: Transcription factor Phox2 upregulates expression of norepinephrine transporter and dopamine β-hydroxylase in adult rat brains.
a novel molecular mechanism that cocaine-activated p38 MAPK-mediated phosphorylation of NET-T30 dictates surface NET availability, and hence, NE transport.
Title: Cocaine up-regulation of the norepinephrine transporter requires threonine 30 phosphorylation by p38 mitogen-activated protein kinase.
Data indicate that selected derivatives showed high in vitro potency and selectivity at SERT, NET, and DAT.
Title: 1-(Aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes and 6-(aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes: a new series of potent and selective triple reuptake inhibitors.

Submit: New GeneRIF Correction See all GeneRIFs (24)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	ISO Inferred from Sequence Orthology more info
enables alpha-tubulin binding	IDA Inferred from Direct Assay more info	PubMed
enables beta-tubulin binding	IDA Inferred from Direct Assay more info	PubMed
enables dopamine:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables dopamine:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoamine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables neurotransmitter transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables neurotransmitter:sodium symporter activity	IEA Inferred from Electronic Annotation more info
enables norepinephrine:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables norepinephrine:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables norepinephrine:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in amino acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in dopamine uptake involved in synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within monoamine transport	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter reuptake	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neurotransmitter transport	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter transport	ISO Inferred from Sequence Orthology more info
involved_in norepinephrine transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in norepinephrine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in norepinephrine uptake	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to pain	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuronal cell body membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: sodium-dependent noradrenaline transporter

Names: NaCl-dependent norepinephrine transporter; neurotransmitter transporter, noradrenal; norepinephrine transporter; solute carrier family 6 (neurotransmitter transporter), member 2; solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2; transmembrane region 4..26 transmembrane region 55..77 transmembrane region 105..123 transmembrane region 136..157

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031343.2 → NP_112633.2 sodium-dependent noradrenaline transporter

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

A6KD51, F1LQW0, Q63380

Related

ENSRNOP00000044317.3, ENSRNOT00000048470.4

Conserved Domains (1) summary

cl00456
Location:56 → 615

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

30183289..30228292 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039098031.2 → XP_038953959.1 sodium-dependent noradrenaline transporter isoform X1

UniProtKB/TrEMBL

A6KD51, F1LQW0, Q63380

Conserved Domains (1) summary

cl00456
Location:56 → 615

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_063278315.1 → XP_063134385.1 sodium-dependent noradrenaline transporter isoform X1

UniProtKB/TrEMBL

A6KD51, F1LQW0, Q63380
XM_063278316.1 → XP_063134386.1 sodium-dependent noradrenaline transporter isoform X1

UniProtKB/TrEMBL

A6KD51, F1LQW0, Q63380
XM_039098029.2 → XP_038953957.1 sodium-dependent noradrenaline transporter isoform X1

UniProtKB/TrEMBL

A6KD51, F1LQW0, Q63380

Conserved Domains (1) summary

cl00456
Location:56 → 615

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain