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    Csnk1g2 casein kinase 1, gamma 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65278, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Csnk1g2provided by RGD
    Official Full Name
    casein kinase 1, gamma 2provided by RGD
    Primary source
    RGD:621407
    See related
    EnsemblRapid:ENSRNOG00000018529 AllianceGenome:RGD:621407
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables protein serine/threonine kinase activity. Involved in protein autophosphorylation. Predicted to be located in cell cortex. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Orthologous to human CSNK1G2 (casein kinase 1 gamma 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 166.6), Thymus (RPKM 138.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Csnk1g2 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (9727430..9746341, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9076739..9095082, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11944957..11963268, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene MAPK interacting serine/threonine kinase 2 Neighboring gene BTB domain containing 2 Neighboring gene secretory carrier membrane protein 4 Neighboring gene large ribosomal subunit protein eL31-like Neighboring gene adenosine deaminase, tRNA-specific 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Casein kinase I gamma subfamily. Molecular cloning, expression, and characterization of three mammalian isoforms and complementation of defects in the Saccharomyces cerevisiae YCK genes. Zhai L, et al. J Biol Chem, 1995 May 26. PMID 7759525
    2. Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7. Chia R, et al. Nat Commun, 2014 Dec 15. PMID 25500533, Free PMC Article
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    casein kinase I isoform gamma-2; casein kinase I
    Names
    CKI-gamma 2
    NP_001029042.1
    NP_075590.2
    XP_006241063.1
    XP_006241065.1
    XP_008763352.1
    XP_038935799.1
    XP_038935800.1
    XP_063120298.1
    XP_063120299.1
    XP_063120300.1
    XP_063120301.1
    XP_063120302.1
    XP_063120303.1
    XP_063120304.1
    XP_063120305.1
    XP_063120306.1
    XP_063120307.1
    XP_063120308.1
    XP_063120309.1
    XP_063120310.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033870.1 → NP_001029042.1  casein kinase I isoform gamma-2 isoform 1

      See identical proteins and their annotated locations for NP_001029042.1

      Status: VALIDATED

      Source sequence(s)
      BC072533
      UniProtKB/Swiss-Prot
      Q62762, Q6IMY5
      Related
      ENSRNOP00000072196.1, ENSRNOT00000080342.3
      Conserved Domains (2) summary
      cd14126
      Location:45 → 332
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:332 → 385
      CK1gamma_C; Casein kinase 1 gamma C terminal

    2. NM_023102.2 → NP_075590.2  casein kinase I isoform gamma-2 isoform 2

      See identical proteins and their annotated locations for NP_075590.2

      Status: VALIDATED

      Source sequence(s)
      BC072533, U22297
      UniProtKB/TrEMBL
      A6K8I3
      Conserved Domains (2) summary
      cd14126
      Location:45 → 331
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:331 → 384
      CK1gamma_C; Casein kinase 1 gamma C terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      9727430..9746341 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264233.1 → XP_063120303.1  casein kinase I isoform X2

      UniProtKB/Swiss-Prot
      Q62762, Q6IMY5

    2. XM_006241001.5 → XP_006241063.1  casein kinase I isoform X1

      See identical proteins and their annotated locations for XP_006241063.1

      UniProtKB/TrEMBL
      A0A0H2UHQ2, A6K8I6
      Related
      ENSRNOP00000025266.6, ENSRNOT00000025266.8
      Conserved Domains (3) summary
      COG0515
      Location:45 → 355
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14126
      Location:45 → 358
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:358 → 400
      CK1gamma_C; Casein kinase 1 gamma C terminal

    3. XM_008765130.4 → XP_008763352.1  casein kinase I isoform X1

      See identical proteins and their annotated locations for XP_008763352.1

      UniProtKB/TrEMBL
      A0A0H2UHQ2, A6K8I6
      Conserved Domains (3) summary
      COG0515
      Location:45 → 355
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14126
      Location:45 → 358
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:358 → 400
      CK1gamma_C; Casein kinase 1 gamma C terminal

    4. XM_039079871.2 → XP_038935799.1  casein kinase I isoform X3

      UniProtKB/TrEMBL
      A6K8I3
      Conserved Domains (2) summary
      cd14126
      Location:45 → 331
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:331 → 384
      CK1gamma_C; Casein kinase 1 gamma C terminal

    5. XM_063264228.1 → XP_063120298.1  casein kinase I isoform X2

      UniProtKB/Swiss-Prot
      Q62762, Q6IMY5

    6. XM_063264230.1 → XP_063120300.1  casein kinase I isoform X2

      UniProtKB/Swiss-Prot
      Q62762, Q6IMY5

    7. XM_063264232.1 → XP_063120302.1  casein kinase I isoform X2

      UniProtKB/Swiss-Prot
      Q62762, Q6IMY5

    8. XM_063264235.1 → XP_063120305.1  casein kinase I isoform X3

      UniProtKB/TrEMBL
      A6K8I3

    9. XM_063264229.1 → XP_063120299.1  casein kinase I isoform X2

      UniProtKB/Swiss-Prot
      Q62762, Q6IMY5

    10. XM_063264236.1 → XP_063120306.1  casein kinase I isoform X3

      UniProtKB/TrEMBL
      A6K8I3

    11. XM_063264234.1 → XP_063120304.1  casein kinase I isoform X2

      UniProtKB/Swiss-Prot
      Q62762, Q6IMY5

    12. XM_063264231.1 → XP_063120301.1  casein kinase I isoform X2

      UniProtKB/Swiss-Prot
      Q62762, Q6IMY5

    13. XM_063264240.1 → XP_063120310.1  casein kinase I isoform X6

    14. XM_039079872.2 → XP_038935800.1  casein kinase I isoform X6

      Conserved Domains (2) summary
      cd14126
      Location:16 → 283
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:283 → 336
      CK1gamma_C; Casein kinase 1 gamma C terminal

    15. XM_063264239.1 → XP_063120309.1  casein kinase I isoform X5

    16. XM_063264238.1 → XP_063120308.1  casein kinase I isoform X5

    17. XM_063264237.1 → XP_063120307.1  casein kinase I isoform X4

    18. XM_006241003.4 → XP_006241065.1  casein kinase I isoform X4

      Conserved Domains (3) summary
      COG0515
      Location:21 → 281
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14126
      Location:16 → 284
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:284 → 326
      CK1gamma_C; Casein kinase 1 gamma C terminal

    RNA

    1. XR_593259.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62762.2 GenPept UniProtKB/Swiss-Prot:Q62762

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools