Mta3 metastasis associated 1 family, member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mta3provided by RGD
Official Full Name: metastasis associated 1 family, member 3provided by RGD
Primary source: RGD:1306803
See related: EnsemblRapid:ENSRNOG00000004685 AllianceGenome:RGD:1306803
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable histone deacetylase binding activity; transcription coactivator activity; and transcription corepressor activity. Predicted to be involved in chromatin remodeling and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of G2/M transition of mitotic cell cycle and positive regulation of granulosa cell proliferation. Predicted to be located in cytoplasm and nucleus. Predicted to be part of NuRD complex. Predicted to be active in nucleoplasm. Orthologous to human MTA3 (metastasis associated 1 family member 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 80.2), Adrenal (RPKM 60.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q12

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (16619575..16739732, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (10867028..10987221, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (6904449..7036929)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results indicated that miR32 and MTA3 may be considered as novel drug targets in the prevention and treatment of liver fibrosis under hyperglycemic conditions. These finding improves the understanding of the progression of liver fibrogenesis.
Title: High glucose promotes hepatic fibrosis via miR‑32/MTA3‑mediated epithelial‑to‑mesenchymal transition.

Submit: New GeneRIF Correction

General gene information

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Markers

D6Got194 (e-PCR)
- UniSTS:111679

d6rat149 (e-PCR)
- UniSTS:122220

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of granulosa cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of granulosa cell proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of NuRD complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NuRD complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: metastasis-associated protein MTA3

Names: metastasis associated 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106705.2 → NP_001100175.2 metastasis-associated protein MTA3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A0G2JTK6, A6H9L6

Related

ENSRNOP00000084094.2, ENSRNOT00000096808.2

Conserved Domains (5) summary

cd11661
Location:270 → 315

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:375 → 420

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd04709
Location:3 → 170

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:150 → 201

ELM2; ELM2 domain

pfam17226
Location:459 → 535

MTA_R1; MTA R1 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

16619575..16739732 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039078111.2 → XP_038934039.1 metastasis-associated protein MTA3 isoform X6

UniProtKB/TrEMBL

A6H9L6

Related

ENSRNOP00000084165.2, ENSRNOT00000108472.2

Conserved Domains (5) summary

cd11661
Location:270 → 315

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:376 → 421

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd04709
Location:3 → 170

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:150 → 201

ELM2; ELM2 domain

pfam17226
Location:460 → 536

MTA_R1; MTA R1 domain
XM_063261374.1 → XP_063117444.1 metastasis-associated protein MTA3 isoform X7

UniProtKB/TrEMBL

A0A8I6A0K7, A6H9L6
XM_063261370.1 → XP_063117440.1 metastasis-associated protein MTA3 isoform X1

UniProtKB/TrEMBL

D3ZPH3

Related

ENSRNOP00000068747.3, ENSRNOT00000079095.3
XM_063261371.1 → XP_063117441.1 metastasis-associated protein MTA3 isoform X2

UniProtKB/TrEMBL

A0A8I5ZYK6, D3ZPH3
XM_039078113.2 → XP_038934041.1 metastasis-associated protein MTA3 isoform X8

UniProtKB/TrEMBL

D3ZPH3

Conserved Domains (5) summary

cd11661
Location:214 → 259

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:320 → 365

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

pfam01448
Location:94 → 145

ELM2; ELM2 domain

pfam17226
Location:404 → 480

MTA_R1; MTA R1 domain

cl02608
Location:2 → 114

BAH; or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...
XM_039078114.2 → XP_038934042.1 metastasis-associated protein MTA3 isoform X8

UniProtKB/TrEMBL

D3ZPH3

Conserved Domains (5) summary

cd11661
Location:214 → 259

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:320 → 365

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

pfam01448
Location:94 → 145

ELM2; ELM2 domain

pfam17226
Location:404 → 480

MTA_R1; MTA R1 domain

cl02608
Location:2 → 114

BAH; or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...
XM_039078110.2 → XP_038934038.1 metastasis-associated protein MTA3 isoform X5

UniProtKB/TrEMBL

A6H9L6

Conserved Domains (5) summary

cd11661
Location:270 → 315

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:376 → 421

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd04709
Location:3 → 170

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:150 → 201

ELM2; ELM2 domain

pfam17226
Location:460 → 536

MTA_R1; MTA R1 domain
XM_063261372.1 → XP_063117442.1 metastasis-associated protein MTA3 isoform X3

UniProtKB/TrEMBL

A6H9L6
XM_063261373.1 → XP_063117443.1 metastasis-associated protein MTA3 isoform X4

UniProtKB/TrEMBL

A6H9L6
XM_039078115.2 → XP_038934043.1 metastasis-associated protein MTA3 isoform X9

UniProtKB/TrEMBL

A6H9L7

Conserved Domains (5) summary

cd11661
Location:270 → 315

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:376 → 421

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd04709
Location:3 → 170

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:150 → 201

ELM2; ELM2 domain

pfam17226
Location:460 → 487

MTA_R1; MTA R1 domain