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    Iws1 interacts with SUPT6H, CTD assembly factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291705, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Iws1provided by RGD
    Official Full Name
    interacts with SUPT6H, CTD assembly factor 1provided by RGD
    Primary source
    RGD:1304762
    See related
    EnsemblRapid:ENSRNOG00000014630 AllianceGenome:RGD:1304762
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1304762
    Summary
    Predicted to be involved in gene expression; regulation of mRNA export from nucleus; and regulation of mRNA processing. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human IWS1 (interacts with SUPT6H, CTD assembly factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 178.4), Spleen (RPKM 130.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Iws1 in Genome Data Viewer
    Location:
    18p12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (23969352..24011560)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (23695496..23737363)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (24849508..24891339)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene LIM zinc finger domain containing 2 Neighboring gene myosin VIIb Neighboring gene uncharacterized LOC134482980 Neighboring gene POTE ankyrin domain family, member F Neighboring gene uncharacterized LOC134482924 Neighboring gene protein C, inactivator of coagulation factors Va and VIIIa

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation. Yoh SM, et al. Genes Dev, 2008 Dec 15. PMID 19141475, Free PMC Article
    2. The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export. Yoh SM, et al. Genes Dev, 2007 Jan 15. PMID 17234882, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124986

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in poly(A)+ mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mRNA export from nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mRNA export from nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transcription elongation-coupled chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription elongation-coupled chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein IWS1 homolog
    Names
    IWS1 homolog
    IWS1, SUPT6H interacting protein
    IWS1-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034918.2 → NP_001030090.1  protein IWS1 homolog isoform 1

      See identical proteins and their annotated locations for NP_001030090.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/Swiss-Prot
      Q3SWT4
      UniProtKB/TrEMBL
      A0A0G2JWE3
      Related
      ENSRNOP00000057730.2, ENSRNOT00000061011.5
      Conserved Domains (2) summary
      PHA02664
      Location:232 → 341
      PHA02664; hypothetical protein; Provisional
      cl00146
      Location:474 → 723
      TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

    2. NM_001398635.1 → NP_001385564.1  protein IWS1 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A0G2JWE3
      Related
      ENSRNOP00000085053.2, ENSRNOT00000102322.2
      Conserved Domains (2) summary
      COG5271
      Location:30 → 402
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cl00146
      Location:474 → 738
      TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      23969352..24011560
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254574.5 → XP_006254636.1  protein IWS1 homolog isoform X5

      UniProtKB/TrEMBL
      A0A8I6A2E0, A0A8I6AF19
      Related
      ENSRNOP00000091736.1, ENSRNOT00000112252.2
      Conserved Domains (2) summary
      PHA02664
      Location:232 → 341
      PHA02664; hypothetical protein; Provisional
      cl00146
      Location:474 → 725
      TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

    2. XM_017600919.3 → XP_017456408.1  protein IWS1 homolog isoform X4

      UniProtKB/TrEMBL
      A0A8I6A2E0, A0A8I6AB64
      Related
      ENSRNOP00000069847.3, ENSRNOT00000085516.3

    3. XM_006254573.5 → XP_006254635.1  protein IWS1 homolog isoform X1

      UniProtKB/TrEMBL
      A0A0G2JWE3
      Conserved Domains (2) summary
      PHA02664
      Location:232 → 341
      PHA02664; hypothetical protein; Provisional
      cl00146
      Location:473 → 737
      TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

    4. XM_006254572.5 → XP_006254634.1  protein IWS1 homolog isoform X2

      See identical proteins and their annotated locations for XP_006254634.1

      UniProtKB/Swiss-Prot
      Q3SWT4
      UniProtKB/TrEMBL
      A0A0G2JWE3
      Conserved Domains (2) summary
      PHA02664
      Location:232 → 341
      PHA02664; hypothetical protein; Provisional
      cl00146
      Location:474 → 723
      TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

    5. XM_063277254.1 → XP_063133324.1  protein IWS1 homolog isoform X3

      UniProtKB/TrEMBL
      A0A0G2JWE3

    RNA

    1. XR_005496012.2 RNA Sequence

    2. XR_005496013.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3SWT4.1 GenPept UniProtKB/Swiss-Prot:Q3SWT4

    Gene LinkOut

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