Aqp7 aquaporin 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aqp7provided by RGD
Official Full Name: aquaporin 7provided by RGD
Primary source: RGD:2145
See related: AllianceGenome:RGD:2145
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: AQP-7
Summary: Enables glycerol channel activity; urea channel activity; and water channel activity. Involved in several processes, including glycerol transmembrane transport; urea transport; and water transport. Located in brush border membrane. Part of ribonucleoprotein complex. Orthologous to several human genes including AQP7 (aquaporin 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 603.8), Heart (RPKM 549.0) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q22

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (60968495..60982618, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (56171649..56186642, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (57358297..57372332, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increased Aquaporin-7 Expression Is Associated with Changes in Rat Brown Adipose Tissue Whitening in Obesity: Impact of Cold Exposure and Bariatric Surgery.
Title: Increased Aquaporin-7 Expression Is Associated with Changes in Rat Brown Adipose Tissue Whitening in Obesity: Impact of Cold Exposure and Bariatric Surgery.
Differential response of cardiac aquaporins to hyperosmotic stress; salutary role of AQP1 against the induced apoptosis.
Title: Differential response of cardiac aquaporins to hyperosmotic stress; salutary role of AQP1 against the induced apoptosis.
Aquaporin-7 and aquaporin-12 modulate the inflammatory phenotype of endocrine pancreatic beta-cells.
Title: Aquaporin-7 and aquaporin-12 modulate the inflammatory phenotype of endocrine pancreatic beta-cells.
AQP7 of visceral adipose tissue may participate in glucose and lipid metabolism associated with diabetes and obesity.
Title: [Expression of aquaporin 7 in perirenal adipose tissue of Otsuka Long-Evans Tokushima Fatty diabetic rats].
Arginine vasopressin down-regulates the expression of AQP7 mRNA in the endolymphatic sac.
Title: [Effect of vasopressin on aquaporin 7 expression in rat inner ear].
These findings document the rapid entry of glycerol and urea in BRIN-BD11 cells, likely mediated by AQP7.
Title: Functional role of aquaglyceroporin 7 expression in the pancreatic beta-cell line BRIN-BD11.
AQP7 and AQP8 may play a role in water movement via the apical domain of small intestine epithelial cells.
Title: Osmotic water permeability of rat intestinal brush border membrane vesicles: involvement of aquaporin-7 and aquaporin-8 and effect of metal ions.
The results indicate that AQP7 is present in the small and large intestine. The higher expression of AQP7 protein at the apical pole of the superficial epithelial cells suggests its involvement in rapid fluid movement through the villus epithelium
Title: Expression and immunolocalization of aquaporin-7 in rat gastrointestinal tract.
Involvement of aquaporin-7 in rat testis development and spermatogenesis.
Title: Possible involvement of aquaporin-7 and -8 in rat testis development and spermatogenesis.

Submit: New GeneRIF Correction

General gene information

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Markers

RH142180 (e-PCR)
- UniSTS:231430

RH133701 (e-PCR)
- UniSTS:216984

Aqp7 (e-PCR), detects polymorphism
- UniSTS:209568

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables glycerol channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycerol channel activity	IDA Inferred from Direct Assay more info	PubMed
enables glycerol channel activity	ISO Inferred from Sequence Orthology more info
enables urea channel activity	IDA Inferred from Direct Assay more info	PubMed
enables urea transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables urea transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables water channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables water channel activity	IDA Inferred from Direct Assay more info	PubMed
enables water channel activity	ISO Inferred from Sequence Orthology more info
enables water channel activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in glycerol transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycerol transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within glycerol transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in glycerol transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within renal water absorption	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in urea transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in urea transport	IDA Inferred from Direct Assay more info	PubMed
involved_in water transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in water transport	IDA Inferred from Direct Assay more info	PubMed
involved_in water transport	ISO Inferred from Sequence Orthology more info
involved_in water transport	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in brush border membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: aquaporin-7

Names: aquaglyceroporin-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429387.1 → NP_001416316.1 aquaporin-7 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P56403, Q8K3F5

UniProtKB/TrEMBL

A6IIT3
NM_001429388.1 → NP_001416317.1 aquaporin-7 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P56403, Q8K3F5

UniProtKB/TrEMBL

A6IIT3
NM_001429389.1 → NP_001416318.1 aquaporin-7 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P56403, Q8K3F5

UniProtKB/TrEMBL

A6IIT3
NM_001429390.1 → NP_001416319.1 aquaporin-7 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P56403, Q8K3F5

UniProtKB/TrEMBL

A6IIT3
NM_001429391.1 → NP_001416320.1 aquaporin-7 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P56403, Q8K3F5

UniProtKB/TrEMBL

A6IIT3
NM_001429392.1 → NP_001416321.1 aquaporin-7 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P56403, Q8K3F5

UniProtKB/TrEMBL

A6IIT3
NM_001429393.1 → NP_001416322.1 aquaporin-7 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005
NM_019157.3 → NP_062030.2 aquaporin-7 isoform 1

See identical proteins and their annotated locations for NP_062030.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P56403, Q8K3F5

UniProtKB/TrEMBL

A6IIT3

Conserved Domains (1) summary

cl00200
Location:15 → 260

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

60968495..60982618 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109352.2 → XP_038965280.1 aquaporin-7 isoform X1

Conserved Domains (1) summary

cl00200
Location:15 → 260

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...