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    Tbxas1 thromboxane A synthase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24886, updated on 4-Jan-2025

    Summary

    Official Symbol
    Tbxas1provided by RGD
    Official Full Name
    thromboxane A synthase 1provided by RGD
    Primary source
    RGD:3826
    See related
    EnsemblRapid:ENSRNOG00000007918 AllianceGenome:RGD:3826
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable heme binding activity; hydroperoxy icosatetraenoate dehydratase activity; and thromboxane-A synthase activity. Involved in several processes, including intracellular chloride ion homeostasis; positive regulation of vasoconstriction; and response to ethanol. Predicted to be located in cytosol and endoplasmic reticulum membrane. Used to study acute necrotizing pancreatitis; artery disease (multiple); brain infarction; glomerulonephritis (multiple); and thrombosis. Biomarker of hydronephrosis. Human ortholog(s) of this gene implicated in Ghosal hematodiaphyseal syndrome and cerebral infarction. Orthologous to human TBXAS1 (thromboxane A synthase 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Spleen (RPKM 48.4), Lung (RPKM 37.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Tbxas1 in Genome Data Viewer
    Location:
    4q23
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (68631841..68803959)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (67664963..67837096)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (66624181..66846745)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene C-type lectin domain family 2, member L Neighboring gene homeodomain interacting protein kinase 2 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene poly (ADP-ribose) polymerase family, member 12 Neighboring gene uncharacterized LOC134486573 Neighboring gene lysine demethylase 7A Neighboring gene RNA, U6 small nuclear 604

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 12-hydroxyheptadecatrienoic acid synthase activity  
    enables heme binding  
    enables heme binding  
    enables hydroperoxy icosatetraenoate dehydratase activity  
    enables hydroperoxy icosatetraenoate dehydratase activity  
    enables iron ion binding  
    enables monooxygenase activity  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen  
    enables thromboxane-A synthase activity  
    enables thromboxane-A synthase activity  
    Process Evidence Code Pubs
    involved_in icosanoid metabolic process  
    involved_in icosanoid metabolic process  
    involved_in intracellular chloride ion homeostasis PubMed 
    involved_in positive regulation of vasoconstriction PubMed 
    involved_in prostaglandin biosynthetic process  
    involved_in prostaglandin biosynthetic process  
    involved_in response to ethanol PubMed 
    involved_in response to fatty acid PubMed 
    Component Evidence Code Pubs
    located_in cytosol  
    located_in cytosol  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum membrane  

    General protein information

    Preferred Names
    thromboxane-A synthase
    Names
    TXA synthase
    TXS
    ThromboxA ane synthase 1
    cytochrome P450 5A1
    hydroperoxy icosatetraenoate dehydratase
    thromboxane A synthase 1, platelet
    NP_036819.1
    XP_038963001.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012687.2NP_036819.1  thromboxane-A synthase

      See identical proteins and their annotated locations for NP_036819.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      P49430
      UniProtKB/TrEMBL
      A6IET4
      Related
      ENSRNOP00000010796.2, ENSRNOT00000010796.6
      Conserved Domains (1) summary
      pfam00067
      Location:47530
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      68631841..68803959
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107073.2XP_038963001.1  thromboxane-A synthase isoform X1

      Conserved Domains (1) summary
      cl41757
      Location:74379
      cytochrome_P450; cytochrome P450 (CYP) superfamily
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