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    Rnf114 ring finger protein 114 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362277, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Rnf114provided by RGD
    Official Full Name
    ring finger protein 114provided by RGD
    Primary source
    RGD:1303139
    See related
    EnsemblRapid:ENSRNOG00000060821 AllianceGenome:RGD:1303139
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zfp313; Znf313
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and plasma membrane. Orthologous to human RNF114 (ring finger protein 114). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Heart (RPKM 210.5), Adrenal (RPKM 183.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rnf114 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (176641456..176653262)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (156222487..156234263)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (164248736..164260499)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 9 member A8 Neighboring gene uncharacterized LOC134486208 Neighboring gene spermatogenesis associated 2 Neighboring gene snail family transcriptional repressor 1 Neighboring gene uncharacterized LOC134486210

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel human zinc finger protein gene ZNF313. Ma YX, et al. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai), 2003 Mar. PMID 12621547
    2. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112560

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF114
    Names
    RING-type E3 ubiquitin transferase RNF114
    zinc finger protein 313
    NP_001001517.1
    XP_008760737.1
    XP_063140300.1
    XP_063140301.1
    XP_063140302.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001517.2 → NP_001001517.1  E3 ubiquitin-protein ligase RNF114

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q4G096, Q6J2U6
      UniProtKB/TrEMBL
      A6JXK5
      Conserved Domains (3) summary
      cd16540
      Location:28 → 69
      RING-HC_RNF114; RING finger, HC subclass, found in RING finger protein 114 (RNF114) and similar proteins
      pfam05605
      Location:141 → 201
      zf-Di19; Drought induced 19 protein (Di19), zinc-binding
      pfam18574
      Location:86 → 118
      zf_C2HC_14; C2HC Zing finger domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      176641456..176653262
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284231.1 → XP_063140301.1  E3 ubiquitin-protein ligase RNF114 isoform X2

    2. XM_063284232.1 → XP_063140302.1  E3 ubiquitin-protein ligase RNF114 isoform X4

    3. XM_063284230.1 → XP_063140300.1  E3 ubiquitin-protein ligase RNF114 isoform X1

    4. XM_008762515.4 → XP_008760737.1  E3 ubiquitin-protein ligase RNF114 isoform X3

      UniProtKB/TrEMBL
      A0A8I5YBW4
      Related
      ENSRNOP00000068785.3, ENSRNOT00000086459.3
      Conserved Domains (1) summary
      pfam05605
      Location:162 → 222
      zf-Di19; Drought induced 19 protein (Di19), zinc-binding
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6J2U6.1 GenPept UniProtKB/Swiss-Prot:Q6J2U6

    Gene LinkOut

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