Htr3a 5-hydroxytryptamine receptor 3A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Htr3aprovided by RGD
Official Full Name: 5-hydroxytryptamine receptor 3Aprovided by RGD
Primary source: RGD:61818
See related: EnsemblRapid:ENSRNOG00000006595 AllianceGenome:RGD:61818
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: 5HT3; Htr3; 5-HT3; 5-HT3A
Summary: Enables serotonin-gated monoatomic cation channel activity. Involved in several processes, including behavioral response to ethanol; positive regulation of ion transmembrane transporter activity; and response to cocaine. Located in axon and neuronal cell body. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic membrane. Biomarker of alcohol dependence. Human ortholog(s) of this gene implicated in alcohol dependence; cocaine dependence; heroin dependence; irritable bowel syndrome; and nicotine dependence. Orthologous to human HTR3A (5-hydroxytryptamine receptor 3A). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Brain (RPKM 17.0), Testes (RPKM 1.3) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 8q23

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (58138514..58150960, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (49242018..49254475, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (53211436..53223878, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FOXD3-mediated transactivation of ALKBH5 promotes neuropathic pain via m[6]A-dependent stabilization of 5-HT3A mRNA in sensory neurons.
Title: FOXD3-mediated transactivation of ALKBH5 promotes neuropathic pain via m(6)A-dependent stabilization of 5-HT3A mRNA in sensory neurons.
Role of 5-HT1A and 5-HT3 receptors in serotonergic activation of sensory neurons in relation to itch and pain behavior in the rat.
Title: Role of 5-HT1A and 5-HT3 receptors in serotonergic activation of sensory neurons in relation to itch and pain behavior in the rat.
Stereological investigation of 5-HT3 receptors in the substantia nigra and dorsal raphe nucleus in the rat.
Title: Stereological investigation of 5-HT(3) receptors in the substantia nigra and dorsal raphe nucleus in the rat.
Results demonstrate that exogenous serotonin acts on 5-HT2 and 5-HT3 receptors in the lumbosacral defecation center and activates the parasympathetic nervous system to enhance colorectal motility in cooperation with noradrenaline and dopamine.
Title: Exogenous serotonin regulates colorectal motility via the 5-HT(2) and 5-HT(3) receptors in the spinal cord of rats.
Results found that 5-HT3aR plays a role in lacrimal gland secretory functions and confirmed that extracellular Ca2+ entry participates in [Ca2+]i mobilization stimulated by 5-HT.
Title: Serotonin hormonally regulates lacrimal gland secretory function via the serotonin type 3a receptor.
Data support a functional role for serotonergic signaling in the mesolimbic pathway on motivated behavior, and demonstrate that 5-HT3 serotonin receptors differentially modulate food consumption in a region-dependent manner.
Title: Contrasting effects of 5-HT(3) receptor stimulation of the nucleus accumbens or ventral tegmentum on food intake in the rat.
This study demonstrates that AITC-induced nociception in vivo depends on TRPA1 and is decreased by the blockade of the NK1 receptor for SP, the H1 receptor for histamine and the 5-HT1A and 3 receptors for 5-HT
Title: TRPA1, substance P, histamine and 5-hydroxytryptamine interact in an interdependent way to induce nociception.
Study concludes that the serotonin 3 receptor does not play a unique role in mediating stress-induced hyperalgesia related to temporomandibular joint nociception.
Title: Inhibition of temporomandibular joint input to medullary dorsal horn neurons by 5HT3 receptor antagonist in female rats.
rats were trained in an operant conditioning task while receiving fluoxetine), tianeptine (serotonin reuptake enhancer, 10mg/kg), buspirone, risperidone (5-HT2A antagonist, 1mg/kg), ondansetron (5-HT3 antagonist, 2mg/kg) or vehicle
Title: Dual role of serotonin in the acquisition and extinction of reward-driven learning: involvement of 5-HT1A, 5-HT2A and 5-HT3 receptors.
The inhibition of I(5-HT3) by WIN55,212-2 is probably new one of peripheral analgesic mechanisms of WIN55,212-2, but the mechanism by which WIN55,212-2 inhibits I(5-HT3) warrants further investigation.
Title: Inhibition of 5-HT(3) receptors-activated currents by cannabinoids in rat trigeminal ganglion neurons.

Submit: New GeneRIF Correction See all GeneRIFs (51)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables excitatory extracellular ligand-gated monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables serotonin binding	IEA Inferred from Electronic Annotation more info
enables serotonin binding	ISO Inferred from Sequence Orthology more info
enables serotonin-gated monoatomic cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables serotonin-gated monoatomic cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables serotonin-gated monoatomic cation channel activity	IEA Inferred from Electronic Annotation more info
enables serotonin-gated monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in behavioral response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	TAS Traceable Author Statement more info	PubMed
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in inorganic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in inorganic cation transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in response to cocaine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in serotonin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in serotonin-gated cation-selective signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in serotonin-gated cation-selective signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cleavage furrow	IEA Inferred from Electronic Annotation more info
located_in cleavage furrow	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
part_of serotonin-activated cation-selective channel complex	IEA Inferred from Electronic Annotation more info
part_of serotonin-activated cation-selective channel complex	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
part_of transmembrane transporter complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 5-hydroxytryptamine receptor 3A

Names: 5-HT-3; 5-HT3 receptor; 5-HT3-A; 5-HT3R; 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic; 5-hydroxytryptamine receptor 3; serotonin receptor 3A; serotonin-gated ion channel receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024394.3 → NP_077370.2 5-hydroxytryptamine receptor 3A precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

P35563

UniProtKB/TrEMBL

Q62999

Related

ENSRNOP00000092870.2, ENSRNOT00000105962.2

Conserved Domains (3) summary

TIGR00860
Location:5 → 477

LIC; Cation transporter family protein

pfam02931
Location:41 → 247

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:254 → 473

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

58138514..58150960 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017595928.3 → XP_017451417.1 5-hydroxytryptamine receptor 3A isoform X2

UniProtKB/TrEMBL

Q62999
XM_006243021.5 → XP_006243083.1 5-hydroxytryptamine receptor 3A isoform X1

UniProtKB/TrEMBL

A0A8L2Q4R5, A6J4A7, Q62999

Related

ENSRNOP00000008965.5, ENSRNOT00000008965.6

Conserved Domains (1) summary

TIGR00860
Location:5 → 482

LIC; Cation transporter family protein
XM_063266201.1 → XP_063122271.1 5-hydroxytryptamine receptor 3A isoform X3

UniProtKB/TrEMBL

Q62999
XM_039082196.2 → XP_038938124.1 5-hydroxytryptamine receptor 3A isoform X5

Conserved Domains (1) summary

TIGR00860
Location:23 → 317

LIC; Cation transporter family protein
XM_039082197.2 → XP_038938125.1 5-hydroxytryptamine receptor 3A isoform X5

Conserved Domains (1) summary

TIGR00860
Location:23 → 317

LIC; Cation transporter family protein
XM_039082195.1 → XP_038938123.1 5-hydroxytryptamine receptor 3A isoform X4

Conserved Domains (1) summary

TIGR00860
Location:18 → 370

LIC; Cation transporter family protein