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    Cck cholecystokinin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25298, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cckprovided by RGD
    Official Full Name
    cholecystokininprovided by RGD
    Primary source
    RGD:2288
    See related
    AllianceGenome:RGD:2288
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables neuropeptide hormone activity. Involved in several processes, including learning or memory; positive regulation of protein metabolic process; and regulation of behavioral fear response. Located in several cellular components, including axon; dendrite; and perikaryon. Is active in GABA-ergic synapse and neuronal dense core vesicle lumen. Used to study cataract. Human ortholog(s) of this gene implicated in alcohol dependence and nicotine dependence. Orthologous to human CCK (cholecystokinin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 513.4) See more
    Orthologs
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    Genomic context

    See Cck in Genome Data Viewer
    Location:
    8q32
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (130031012..130037702, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (121153499..121160194, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (130120525..130127515, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene trafficking kinesin protein 1 Neighboring gene uncharacterized LOC120094301 Neighboring gene uncharacterized LOC120094300 Neighboring gene uncharacterized LOC120094388 Neighboring gene ATP synthase inhibitory factor subunit 1, pseudogene 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hormone activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables neuropeptide hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables neuropeptide hormone activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables neuropeptide hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables neuropeptide hormone activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables neuropeptide hormone activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables peptide hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic DNA fragmentation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within axonogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in axonogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in cholecystokinin signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in digestion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in digestion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in eating behavior IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within eating behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in eating behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrial depolarization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of appetite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of behavioral fear response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of eating behavior IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of behavioral fear response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of glutamate secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of pancreatic amylase secretion by cholecystokinin signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in release of cytochrome c from mitochondria IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synaptic signaling via neuropeptide EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in synaptic signaling via neuropeptide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in visual learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in axon hillock IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon initial segment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in neuronal dense core vesicle lumen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in terminal bouton IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012829.2NP_036961.1  cholecystokinin preproprotein

      See identical proteins and their annotated locations for NP_036961.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      P01355
      UniProtKB/TrEMBL
      A6I437
      Conserved Domains (1) summary
      pfam00918
      Location:4115
      Gastrin; Gastrin/cholecystokinin family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      130031012..130037702 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080873.2XP_038936801.1  cholecystokinin isoform X1

      Conserved Domains (1) summary
      pfam00918
      Location:4141
      Gastrin; Gastrin/cholecystokinin family