Tshb thyroid stimulating hormone subunit beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tshbprovided by RGD
Official Full Name: thyroid stimulating hormone subunit betaprovided by RGD
Primary source: RGD:3910
See related: EnsemblRapid:ENSRNOG00000016793 AllianceGenome:RGD:3910
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable hormone activity. Involved in response to calcium ion; response to estrogen; and response to vitamin A. Predicted to be active in cytoplasm and extracellular space. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 4 and hypothyroidism. Orthologous to human TSHB (thyroid stimulating hormone subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 26.1), Spleen (RPKM 13.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (192913171..192918054, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (190224676..190229559, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (205207799..205215199, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data add new insight to an important role of T3 in rapidly regulating TSH beta gene expression at posttranscriptional level.
Title: T3 rapidly modulates TSHβ mRNA stability and translational rate in the pituitary of hypothyroid rats.
TSH action stimulates the phosphorylation of hsp-90 in FRTL-5 thyroid cells
Title: Phosphorylation of heat shock protein-90 by TSH in FRTL-5 thyroid cells.
TSH regulates Id2 expression, but that Id2 does not alter the expression of thyroid-specific genes, such as Tg, in FRTL-5 thyroid cells
Title: Regulation of inhibitors of differentiation family proteins by thyroid-stimulating hormone in FRTL-5 thyroid cells.
Results clearly show that there are diurnal changes in TSH expression and accumulation in rat PT-TSH cells and suggest that these fluctuations are regulated by melatonin.
Title: Diurnal change of thyroid-stimulating hormone mRNA expression in the rat pars tuberalis.

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General gene information

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Markers

Tshb (e-PCR), detects polymorphism
- UniSTS:507407

Tshb (e-PCR), detects polymorphism
- UniSTS:518828

RH94521 (e-PCR)
- UniSTS:119769

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hormone activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to calcium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estrogen	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin A	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: thyrotropin subunit beta

Names: TSH-B; TSH-beta; thyroid stimulating hormone, beta subunit; thyrotropin beta chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.