Ripk3 receptor-interacting serine-threonine kinase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ripk3provided by RGD
Official Full Name: receptor-interacting serine-threonine kinase 3provided by RGD
Primary source: RGD:628899
See related: EnsemblRapid:ENSRNOG00000020465 AllianceGenome:RGD:628899
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rip3; Hcyp2
Summary: Predicted to enable identical protein binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including hematopoietic or lymphoid organ development; necroptotic process; and regulation of macromolecule metabolic process. Predicted to act upstream of or within with a positive effect on non-canonical NF-kappaB signal transduction. Predicted to act upstream of or within several processes, including positive regulation of intrinsic apoptotic signaling pathway; positive regulation of ligase activity; and positive regulation of reactive oxygen species metabolic process. Predicted to be located in cytosol and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Orthologous to human RIPK3 (receptor interacting serine/threonine kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 101.3), Thymus (RPKM 69.4) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p13

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (33253071..33262025, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (29283153..29292107, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (34470796..34479741, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Receptor interacting protein kinase-3 mediates both myopathy and cardiomyopathy in preclinical animal models of Duchenne muscular dystrophy.
Title: Receptor interacting protein kinase-3 mediates both myopathy and cardiomyopathy in preclinical animal models of Duchenne muscular dystrophy.
Receptor-interacting protein 3-phosphorylated Ca[2+] /calmodulin-dependent protein kinase II and mixed lineage kinase domain-like protein mediate intracerebral hemorrhage-induced neuronal necroptosis.
Title: Receptor-interacting protein 3-phosphorylated Ca(2+) /calmodulin-dependent protein kinase II and mixed lineage kinase domain-like protein mediate intracerebral hemorrhage-induced neuronal necroptosis.
Inhibition of RIP1-RIP3-mediated necroptosis attenuates renal fibrosis via Wnt3alpha/beta-catenin/GSK-3beta signaling in unilateral ureteral obstruction.
Title: Inhibition of RIP1-RIP3-mediated necroptosis attenuates renal fibrosis via Wnt3α/β-catenin/GSK-3β signaling in unilateral ureteral obstruction.
RIP3 Contributes to Cardiac Hypertrophy by Influencing MLKL-Mediated Calcium Influx.
Title: RIP3 Contributes to Cardiac Hypertrophy by Influencing MLKL-Mediated Calcium Influx.
RIPK1-RIPK3 mediates myocardial fibrosis in type 2 diabetes mellitus by impairing autophagic flux of cardiac fibroblasts.
Title: RIPK1-RIPK3 mediates myocardial fibrosis in type 2 diabetes mellitus by impairing autophagic flux of cardiac fibroblasts.
Protective action of ultrasound-guided intraparenchymal transplantation of BMSCs in adriamycin nephropathy rats through the RIPK3/MLKL and NLRP3 pathways.
Title: Protective action of ultrasound-guided intraparenchymal transplantation of BMSCs in adriamycin nephropathy rats through the RIPK3/MLKL and NLRP3 pathways.
TNFAIP3-upregulated RIP3 exacerbates acute pancreatitis via activating NLRP3 inflammasome.
Title: TNFAIP3-upregulated RIP3 exacerbates acute pancreatitis via activating NLRP3 inflammasome.
RIP3 Inhibition ameliorates chronic constriction injury-induced neuropathic pain by suppressing JNK signaling.
Title: RIP3 Inhibition ameliorates chronic constriction injury-induced neuropathic pain by suppressing JNK signaling.
Effects of 17-AAG on the RIP1/RIP3/MLKL pathway during the development of heart failure following myocardial infarction in rats.
Title: Effects of 17-AAG on the RIP1/RIP3/MLKL pathway during the development of heart failure following myocardial infarction in rats.
miR-325-3p Protects Neurons from Oxygen-Glucose Deprivation and Reoxygenation Injury via Inhibition of RIP3.
Title: miR-325-3p Protects Neurons from Oxygen-Glucose Deprivation and Reoxygenation Injury via Inhibition of RIP3.

Submit: New GeneRIF Correction See all GeneRIFs (32)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in T cell differentiation in thymus	ISO Inferred from Sequence Orthology more info
involved_in T cell differentiation in thymus	ISS Inferred from Sequence or Structural Similarity more info
involved_in T cell homeostasis	ISO Inferred from Sequence Orthology more info
involved_in T cell homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in activation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in activation of protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in amyloid fibril formation	IEA Inferred from Electronic Annotation more info
involved_in amyloid fibril formation	ISO Inferred from Sequence Orthology more info
involved_in amyloid fibril formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISS Inferred from Sequence or Structural Similarity more info
involved_in execution phase of necroptosis	ISO Inferred from Sequence Orthology more info
involved_in execution phase of necroptosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in lymph node development	ISO Inferred from Sequence Orthology more info
involved_in lymph node development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within necroptotic process	ISO Inferred from Sequence Orthology more info
involved_in necroptotic process	ISO Inferred from Sequence Orthology more info
involved_in necroptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in necroptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in necroptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_positive_effect non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of ligase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of necroptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of necroptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of necroptotic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of oxidoreductase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transferase activity	ISO Inferred from Sequence Orthology more info
involved_in programmed necrotic cell death	ISO Inferred from Sequence Orthology more info
acts_upstream_of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation	ISO Inferred from Sequence Orthology more info
involved_in regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of T cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in regulation of T cell mediated cytotoxicity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of activated T cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of activation-induced cell death of T cells	ISO Inferred from Sequence Orthology more info
involved_in regulation of activation-induced cell death of T cells	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of adaptive immune response	ISO Inferred from Sequence Orthology more info
involved_in regulation of adaptive immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in regulation of type II interferon production	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in spleen development	ISO Inferred from Sequence Orthology more info
involved_in spleen development	ISS Inferred from Sequence or Structural Similarity more info
involved_in thymus development	ISO Inferred from Sequence Orthology more info
involved_in thymus development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: receptor-interacting serine/threonine-protein kinase 3

Names: RIP-3; RIP-like protein kinase 3; homocysteine respondent protein HCYP2; receptor-interacting protein 3

NP_647558.2

EC 2.7.11.1

XP_038948911.1

EC 2.7.11.1

XP_063130035.1

EC 2.7.11.1

XP_063130036.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_139342.2 → NP_647558.2 receptor-interacting serine/threonine-protein kinase 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/Swiss-Prot

B0BMV6, Q9Z2P5

UniProtKB/TrEMBL

A0A8I6A4Y2

Related

ENSRNOP00000027759.4, ENSRNOT00000027759.6

Conserved Domains (2) summary

pfam12721
Location:408 → 458

RHIM; RIP homotypic interaction motif

cl21453
Location:28 → 285

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

33253071..33262025 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063273966.1 → XP_063130036.1 receptor-interacting serine/threonine-protein kinase 3 isoform X1

UniProtKB/Swiss-Prot

B0BMV6, Q9Z2P5

UniProtKB/TrEMBL

A0A8I6A4Y2
XM_063273965.1 → XP_063130035.1 receptor-interacting serine/threonine-protein kinase 3 isoform X1

UniProtKB/Swiss-Prot

B0BMV6, Q9Z2P5

UniProtKB/TrEMBL

A0A8I6A4Y2
XM_039092983.2 → XP_038948911.1 receptor-interacting serine/threonine-protein kinase 3 isoform X2

UniProtKB/TrEMBL

A0A8I6A4Y2

Conserved Domains (2) summary

pfam12721
Location:344 → 394

RHIM; RIP homotypic interaction motif

cl21453
Location:1 → 217

PKc_like; Protein Kinases, catalytic domain